Nature Search

Publisher Correction: Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

Xinyu Qi
Chuyu Yun
Jie Qiao
Amendments and Corrections30 Aug 2019
Nature Medicine

Volume: 25, P: 1459
Author Correction: Alkaline ceramidase 1–mediated platelet ceramide catabolism mitigates vascular inflammation and abdominal aortic aneurysm formation

Xu Zhang
Ze Gong
Wei Kong
Amendments and Corrections01 Sept 2025
Nature Cardiovascular Research

Volume: 4, P: 1206
Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism

Thyroid hormones regulate systemic glucose metabolism through incompletely understood mechanisms. Here the authors report that hepatic thyroid hormone receptor β mediates the effects of the thyroid hormone T3 on systemic glucose homeostasis by modulating GLP-1 levels through suppression of hepatic CYP8B1 expression and bile acid mediated inhibition of intestinal FXR signalling.

Ying Yan
Zhoumin Niu
Hao Ying
ResearchOpen Access27 Oct 2022
Nature Communications

Volume: 13, P: 1-16
Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

Obesity induces hypoxia and upregulation of HIF-2α in the gastrointestinal tract, resulting in excess ceramide production and exacerbation of NAFLD.

Cen Xie
Tomoki Yagai
Frank J Gonzalez
Research09 Oct 2017
Nature Medicine

Volume: 23, P: 1298-1308
Elevated nitric oxide during colitis restrains GM-CSF production in ILC3 cells via suppressing an AhR-Cyp4f13-NF-κB axis

Metabolic processes lead to the production of bioactive gases, such as nitric oxide, which may play roles in the gut immune homeostasis. Here authors show that genomic deletion of Nos2 in mice aggravates colitis in experimental models via an Aryl-Hydrocarbon-Receptor-mediated pathway in type 3 innate lymphoid cells.

Xingyu Zhao
Jun Li
Chao Zhong
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-18
Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids

The gut commensal Christensenalla minuta produces a previously undescribed class of secondary bile acids that counteract features of metabolic disease and are depleted in patients with type 2 diabetes.

Chang Liu
Meng-Xuan Du
Shuang-Jiang Liu
Research17 Jan 2024
Nature Microbiology

Volume: 9, P: 434-450
Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon–carbon linkage reactions

Some thiamine diphosphate-dependent enzymes are powerful biocatalysts, forming carbon–carbon bonds between two α-keto acids, but their catalytic properties have been poorly understood. Now the substrate selectivity and catalytic stereoselectivity of two representative enzymes, CsmA and BbmA, have been fully characterized. Enzymatic total synthesis using these enzymes generates diverse carboligation products.

Tan Liu
Guiyang Wang
Ming Ma
Research14 May 2025
Nature Chemistry

Volume: 17, P: 1107-1118
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

The nuclear farnesoid X receptor (FXR) is activated by bile acids and influences energy metabolism. Here, the authors report a small molecule inhibitor of FXR, glycine-ß-muricholic acid, which inhibits FXR in the intestine and improves metabolic homeostasis by repressing intestinal ceramide synthesis.

Changtao Jiang
Cen Xie
Frank J. Gonzalez
ResearchOpen Access15 Dec 2015
Nature Communications

Volume: 6, P: 1-18
Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis

CYSLTR2 and P2RY6 are identified as endogenous ceramide receptors, and inhibition of these ameliorates atherosclerosis, particularly in chronic-kidney-disease-associated cardiovascular disease.

Siting Zhang
Hui Lin
Wei Kong
Research06 Mar 2025
Nature

Volume: 641, P: 476-485
Adipose triglyceride lipase suppresses noncanonical inflammasome by hydrolyzing LPS

Adipose triglyceride lipase (ATGL), an enzyme in fatty acid metabolism, was identified as a negative regulator of the noncanonical inflammasome. ATGL binds to lipopolysaccharide and catalyzes the hydrolysis of fatty acid side chains blocking inflammasome activation.

Weitao Li
Qiannv Liu
Pengyan Xia
Research27 Feb 2024
Nature Chemical Biology

Volume: 20, P: 1434-1442
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

Tempol is an antioxidant that reduces the body weight of mice on a high-fat diet. Li et al.now provide a mechanistic link by demonstrating that tempol affects the intestinal microbiota, which leads to a change in the composition of bile acids and suppression of FXR signalling.

Fei Li
Changtao Jiang
Frank J. Gonzalez
Research24 Sept 2013
Nature Communications

Volume: 4, P: 1-10
Hepatic HuR modulates lipid homeostasis in response to high-fat diet

Human antigen R (HuR) is a RNA binding protein involved in the regulation of many cellular functions. Here the authors show that, hepatocyte specific deletion of HuR exacerbates high-fat diet-induced NAFLD in mice by regulating transcripts involved in lipid transport and ATP synthesis.

Zhuojun Zhang
Chen Zong
Wengong Wang
ResearchOpen Access16 Jun 2020
Nature Communications

Volume: 11, P: 1-12
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Metformin decreases the levels of Bacteroides fragilis while increasing the bile acid GUDCA to antagonize intestinal FXR and improves the metabolic health of humans and mice.

Lulu Sun
Cen Xie
Changtao Jiang
Research05 Nov 2018
Nature Medicine

Volume: 24, P: 1919-1929
PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis

Bile acids have been linked to the development of inflammatory bowel diseases, such as colitis. Here the authors show that bile acid levels in mice are controlled by a circular feedback system involving the nuclear receptors PPARα and FXR, and that this system is dysregulated in colitis.

Xueyan Zhou
Lijuan Cao
Haiping Hao
ResearchOpen Access03 Sept 2014
Nature Communications

Volume: 5, P: 1-15
Lithocholic acid phenocopies anti-ageing effects of calorie restriction

Lithocholic acid is one of the metabolites upregulated during calorie restriction, and treatment of mice, worms and flies with this bile acid alone can reproduce the health benefits of calorie restriction.

Qi Qu
Yan Chen
Sheng-Cai Lin
ResearchOpen Access18 Dec 2024
Nature

Volume: 643, P: 192-200
COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity

Yiting Jia
Meili Wang
Wei Kong
ResearchOpen Access04 Jun 2018
Cell Death & Disease

Volume: 9, P: 1-22
Author Correction: Lithocholic acid phenocopies anti-ageing effects of calorie restriction

Qi Qu
Yan Chen
Sheng-Cai Lin
Amendments and CorrectionsOpen Access28 Jan 2025
Nature

Volume: 638, P: E6
Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α

Non-alcoholic steatohepatitis has with few well-defined biomarkers or clinically effective treatments but is promoted by inflammation. Here, the authors find an active lipid [So(d18:1)] that is significantly changed in patients and promotes inflammation by directly inhibiting macrophage HIF-2α.

Jialin Xia
Hong Chen
Yanli Pang
ResearchOpen Access04 Jun 2024
Nature Communications

Volume: 15, P: 1-16
Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy

TGR5 activation improves myocardial lipid accumulation and cardiac dysfunction in diabetic mice, offering promise for managing diabetic cardiomyopathy.

Hu Wang
Jiaxing Wang
Ming Xu
ResearchOpen Access02 May 2024
Nature Metabolism

Volume: 6, P: 1161-1177
The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice

The metabolite agmatine derived from the gut microbiota contributes to a polycystic ovary syndrome-like phenotype in female mice and inhibits the secretion of glucagon-like peptide-1, thereby contributing to metabolic and ovarian dysfunction.

Chuyu Yun
Sen Yan
Yanli Pang
Research20 May 2024
Nature Metabolism

Volume: 6, P: 947-962
Proline uptake promotes activation of lymphoid tissue inducer cells to maintain gut homeostasis

Defects in interleukin-22 production and group 3 innate lymphoid cells are correlated with aggravated gut inflammation. Wu et al. find that proline uptake via the proline transporter Slc6a7 is involved in activation of lymphoid tissue inducer cells and interleukin-22 production in the gut, and that dietary supplementation with proline alleviates colitis in a mouse model.

Di Wu
Zongxian Li
Chao Zhong
Research19 Oct 2023
Nature Metabolism

Volume: 5, P: 1953-1968
Alkaline ceramidase 1–mediated platelet ceramide catabolism mitigates vascular inflammation and abdominal aortic aneurysm formation

Zhang et al. report that alkaline ceramidase 1–mediated ceramide degradation in platelets alleviated platelet-involved vascular inflammation and abdominal aortic aneurysm formation but without affecting hemostasis and thrombosis.

Xu Zhang
Ze Gong
Wei Kong
Research16 Nov 2023
Nature Cardiovascular Research

Volume: 2, P: 1173-1189
Gut bacteria alleviate smoking-related NASH by degrading gut nicotine

Nicotine accumulates in the intestine during tobacco smoking and accelerates the progression of non-alcoholic fatty liver disease to non-alcoholic steatohepatitis (NASH), but it can be degraded effectively by the human symbiont Bacteroides xylanisolvens.

Bo Chen
Lulu Sun
Changtao Jiang
Research19 Oct 2022
Nature

Volume: 610, P: 562-568
Intestinal MYC modulates obesity-related metabolic dysfunction

Inhibition of intestinal MYC is shown to have beneficial metabolic effects by promoting GLP-1 secretion and reducing ceramide production.

Yuhong Luo
Shoumei Yang
Frank J. Gonzalez
Research01 Jul 2021
Nature Metabolism

Volume: 3, P: 923-939
Structural basis of GPBAR activation and bile acid recognition

Using cryo-electron microscopy, the authors report the structures of G-protein-coupled bile acid receptor–G_s complexes and reveal the structural basis of bile acid recognition.

Fan Yang
Chunyou Mao
Yan Zhang
Research22 Jul 2020
Nature

Volume: 587, P: 499-504
Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

Modifying the gut microbiota, bile acid, or IL-22 may offer an alternative approach for the treatment of polycystic ovary syndrome.

Xinyu Qi
Chuyu Yun
Jie Qiao
Research22 Jul 2019
Nature Medicine

Volume: 25, P: 1225-1233
The TET3 inflammasome senses unique long HSV-1 proteins for virus particle budding from the nucleus

Qiannv Liu
Weitao Li
Pengyan Xia
Research08 Oct 2024
Cellular & Molecular Immunology

Volume: 21, P: 1322-1334
The role of hypoxia-inducible factors in metabolic diseases

This Review focuses on the function of hypoxia-inducible factors (HIFs) in controlling metabolism and their influence in metabolic diseases (including obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease). The therapeutic potential of targeting HIFs for the treatment of metabolic diseases will also be discussed.

Frank J. Gonzalez
Cen Xie
Changtao Jiang
Reviews01 Oct 2018
Nature Reviews Endocrinology

Volume: 15, P: 21-32
Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice

Wenqiang Li
Yiting Jia
Wei Kong
ResearchOpen Access17 Jul 2023
npj Science of Food

Volume: 7, P: 1-12
B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis

Xing Du
Xiaolong Ma
Xian Wang
ResearchOpen Access13 Mar 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-16
Planar binary-phase lens for super-oscillatory optical hollow needles

Gang Chen
Zhixiang Wu
Xiangang Luo
ResearchOpen Access05 Jul 2017
Scientific Reports

Volume: 7, P: 1-10

Search

Publisher Correction: Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

Author Correction: Alkaline ceramidase 1–mediated platelet ceramide catabolism mitigates vascular inflammation and abdominal aortic aneurysm formation

Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

Elevated nitric oxide during colitis restrains GM-CSF production in ILC3 cells via suppressing an AhR-Cyp4f13-NF-κB axis

Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids

Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon–carbon linkage reactions

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis

Adipose triglyceride lipase suppresses noncanonical inflammasome by hydrolyzing LPS

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

Hepatic HuR modulates lipid homeostasis in response to high-fat diet

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis

Lithocholic acid phenocopies anti-ageing effects of calorie restriction

COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity

Author Correction: Lithocholic acid phenocopies anti-ageing effects of calorie restriction

Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α

Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy

The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice

Proline uptake promotes activation of lymphoid tissue inducer cells to maintain gut homeostasis

Alkaline ceramidase 1–mediated platelet ceramide catabolism mitigates vascular inflammation and abdominal aortic aneurysm formation

Gut bacteria alleviate smoking-related NASH by degrading gut nicotine

Intestinal MYC modulates obesity-related metabolic dysfunction

Structural basis of GPBAR activation and bile acid recognition

Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

The TET3 inflammasome senses unique long HSV-1 proteins for virus particle budding from the nucleus

The role of hypoxia-inducible factors in metabolic diseases

Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice

B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis

Planar binary-phase lens for super-oscillatory optical hollow needles

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