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Showing 1–3 of 3 results
Advanced filters: Author: Chantal Alkhoury Clear advanced filters

  • Alkhoury et al. show that the class 3 phosphatidylinositol-3-kinase Vps15 subunit coactivates the circadian clock transcription factor Bmal1–Clock for metabolic rhythmicity in the liver and promotes pro-anabolic de novo purine synthesis.

    • Chantal Alkhoury
    • Nathaniel F. Henneman
    • Ganna Panasyuk
    ResearchOpen Access
    Nature Cell Biology
    Volume: 25, P: 975-988

  • Lamin A/C protects alveolar macrophages against nuclear envelope rupture and DNA damage, but it erodes during aging. Lack of lamin A/C leads to senescence and an aging signature, resulting in vulnerability to influenza virus and lung cancer growth.

    • Nilushi S. De Silva
    • Johan Siewiera
    • Nicolas Manel
    Research
    Nature Aging
    Volume: 3, P: 1251-1268

  • Peroxisome Proliferator Activated Receptor alpha (PPARα) drives fatty acid catabolism. Here, the authors show that in liver of autophagy deficient class 3 phosphoinositide 3-kinase mutant mice PPARα transcriptional repressors fail to degrade in lysosomes and accumulate leading to PPARα inhibition and blunted transcriptional responses during fasting.

    • Anton Iershov
    • Ivan Nemazanyy
    • Ganna Panasyuk
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18