Lothar Hennighausen and colleagues identify 440 mammary-specific super-enhancers in mouse and focus on the STAT5-regulated Wap gene. Genetic dissection of the Wap super-enhancer suggests an internal hierarchy, as mutations in one of the constituent enhancers incapacitate the entire regulatory region.
- Ha Youn Shin
- Michaela Willi
- Lothar Hennighausen