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Showing 1–4 of 4 results
Advanced filters: Author: Charlene Bashore Clear advanced filters

  • New optical methods for investigating the activity of small molecules in cells may facilitate development of anticancer therapeutics. Here, the authors use a super-resolution optical platform and single molecule tracking to gain insight into WRN regulation in cancer.

    • Fernando Rodríguez Pérez
    • Dean Natwick
    • Stephen Basham
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Discovery of macrocyclic ligands to the 19S regulatory particle protein PSMD2 enables the synthesis of heterobifunctional molecules that demonstrate proof-of-concept, targeted degradation of BRD4 through direct engagement of the 26S proteasome.

    • Charlene Bashore
    • Sumit Prakash
    • Erin C. Dueber
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 55-63

  • Electron microscopy and biochemistry analyses reveal that the deubiquitinase Ubp6, in its ubiquitin-bound form, inhibits substrate deubiquitination by Rpn11, stabilizes the proteasome in a substrate-engaged conformation and interferes with the engagement of a subsequent substrate.

    • Charlene Bashore
    • Corey M Dambacher
    • Andreas Martin
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 712-719