Nature Search

Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsites

Head and neck squamous cell carcinoma (HNSCC) frequency and risk factors vary considerably across regions and ancestries. Here, the authors conduct a multi-ancestry genome-wide association study and fine mapping study of HNSCC subsites in cohorts from multiple continents, finding susceptibility and protective loci, gene-environment interactions, and gene variants related to immune response.

Elmira Ebrahimi
Apiwat Sangphukieo
Tom Dudding
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-18
Simian virus 40 in a human cancer

Federico Soriano
Charles E. Shelburne
Muharrem Gökcen
Research31 May 1974
Nature

Volume: 249, P: 421-424
Polarity and the Degradation of mRNA

DANIEL E. MORSE
CHARLES YANOFSKY
Research25 Oct 1969
Nature

Volume: 224, P: 329-331
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Drosophila muscle myosin heavy chain encoded by a single gene in a cluster of muscle mutations

Sanford I. Bernstein
Kaname Mogami
Charles P. Emerson Jr
Research31 Mar 1983
Nature

Volume: 302, P: 393-397
Heterogeneity in Genetic Control of Phenylalanine Metabolism in Man

DAVID ROSENBLATT
CHARLES R. SCRIVER
Research18 May 1968
Nature

Volume: 218, P: 677-678
Meta-analyses identify DNA methylation associated with kidney function and damage

Many genetic loci have been identified to be associated with kidney disease, but the molecular mechanisms are not well understood. Here, the authors perform epigenome-wide association studies on kidney function measures to identify epigenetic marks and pathways involved in kidney function.

Pascal Schlosser
Adrienne Tin
Alexander Teumer
ResearchOpen Access09 Dec 2021
Nature Communications

Volume: 12, P: 1-16
Mechanism of Streptomycin Action on Bacteria: A Unitary Hypothesis

CHARLES R. SPOTTS
R. Y. STANIER
Research18 Nov 1961
Nature

Volume: 192, P: 633-637
Role of the Amino-Acid ‘Code’ and of Selection for Conformation in the Evolution of Proteins

CHARLES J. EPSTEIN
Research02 Apr 1966
Nature

Volume: 210, P: 25-28
Medroxyprogesterone interferes with ovarian steroid protection against coronary vasospasm

Koichi Miyagawa
Josef Rösch
Kent Hermsmeyer
Research01 Mar 1997
Nature Medicine

Volume: 3, P: 324-327
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus

Serum urate concentration can be studied in large datasets to find genetic and epigenetic loci that may be related to cardiometabolic traits. Here the authors identify and replicate 100 urate-associated CpGs, which provide insights into urate GWAS loci and shared CpGs of urate and cardiometabolic traits.

Adrienne Tin
Pascal Schlosser
Anna Köttgen
ResearchOpen Access09 Dec 2021
Nature Communications

Volume: 12, P: 1-18
Effect of Parathyroid Extract on Citric Acid Concentration in the Rat Kidney

A. KOMÁRKOVÁ
J. VOSTÁL
V. PACOVSKÝ
Research16 Jan 1960
Nature

Volume: 185, P: 173-174
Nutrient and sediment retention in Andean raised-field agriculture

Heath J. Carney
Michael W. Binford
Charles R. Goldman
Research08 Jul 1993
Nature

Volume: 364, P: 131-133
Mechanosensitive channels transduce osmosensitivity in supraoptic neurons

Stéphane H. R. Oliet
Charles Bourque
Research22 Jul 1993
Nature

Volume: 364, P: 341-343
Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins

Charles Brenner
Preston Garrison
John M. Lowenstein
Research01 Mar 1997
Nature Structural Biology

Volume: 4, P: 231-238
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Collective cell guidance by cooperative intercellular forces

Dhananjay Tambe
Charles Hardin
Xavier Trepat
ResearchOpen Access16 Dec 2010
Nature Precedings

P: 1
Epithelial homing of γδ T cells?

CHARLES A. JANEWAY JR
Research14 Sept 1989
Nature

Volume: 341, P: 114
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Cristian Pattaro
Alexander Teumer
Caroline S. Fox
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-19
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

Zhishan Chen
Xingyi Guo
Wei Zheng
ResearchOpen Access26 Apr 2024
Nature Communications

Volume: 15, P: 1-17
Effects of Asphyxia on Renal Function in the Newborn Piglet

Charles T Alward
Jerry B Hook
Michael D Bailie
Research01 Mar 1978
Pediatric Research

Volume: 12, P: 225-228
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Frontiers of the immune system

Charles A. Janeway Jr
News & Views30 Jun 1988
Nature

Volume: 333, P: 804-806
Discovery of common and rare genetic risk variants for colorectal cancer

Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.

Jeroen R. Huyghe
Stephanie A. Bien
Ulrike Peters
Research03 Dec 2018
Nature Genetics

Volume: 51, P: 76-87
Effect of Calciotropic Hormones and Cyclic Nucleotides on Aminoaciduria and Phosphaturia

Roderick R Mcinnes
Charles R Scriver
Research01 Mar 1980
Pediatric Research

Volume: 14, P: 218-223
The Translational and Rotational Dynamics of a Colloid Moving Along the Air-Liquid Interface of a Thin Film

Subhabrata Das
Joel Koplik
Ponisseril Somasundaran
ResearchOpen Access11 Jun 2018
Scientific Reports

Volume: 8, P: 1-13
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Genetic variants associated with susceptibility to pancreatic cancer have been identified using genome wide association studies (GWAS). Here, the authors combine data from over 9000 patients and perform a meta-analysis to identify five novel loci linked to pancreatic cancer.

Alison P. Klein
Brian M. Wolpin
Laufey T. Amundadottir
ResearchOpen Access08 Feb 2018
Nature Communications

Volume: 9, P: 1-11
Francis Crick (1916–2004)

Alexander Rich and Charles F. Stevens, respectively an early collaborator of Crick's and a long-standing colleague at the Salk Institute, describe the life and work of one of the great thinkers of twentieth-century biology.

Alexander Rich
Charles F. Stevens
News & Views18 Aug 2004
Nature

Volume: 430, P: 845-847
Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter

Mark S. Schmidt
Charles Brenner
Research12 Jul 2019
Nature Metabolism

Volume: 1, P: 660-661
A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules

Brunella Franco
Silvana Guioli
Andrea Ballabio
Research10 Oct 1991
Nature

Volume: 353, P: 529-536
A mutation that changes cell movement and cell fate in the zebrafish embryo

Charles B. Kimmel
Donald A. Kane
Mary B. Rothman
Research26 Jan 1989
Nature

Volume: 337, P: 358-362
Myelin-reactive B cells exacerbate CD4⁺ T cell-driven CNS autoimmunity in an IL-23-dependent manner

B cells are crucial in multiple sclerosis (MS) pathology but the mechanisms are incompletely understood. In a mouse model of MS, the authors show that B cells make IL-23, and that IL-23 invokes meningeal inflammation and CNS presence of T peripheral helper cells.

Mohamed Reda Fazazi
Prenitha Mercy Ignatius Arokia Doss
Manu Rangachari
ResearchOpen Access26 Jun 2024
Nature Communications

Volume: 15, P: 1-17
Genome-wide association study identifies common variants associated with breast cancer in South African Black women

Although the genetic basis of breast cancer has been explored, most studies have been on European populations. Here, the authors perform a genome-wide association study of breast cancer in Black South African women to identify new genetic variants associated with breast cancer risk.

Mahtaab Hayat
Wenlong C. Chen
Jean-Tristan Brandenburg
ResearchOpen Access14 Apr 2025
Nature Communications

Volume: 16, P: 1-11
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Bin Zhou
Kate E. Sheffer
Majid Ezzati
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 2885-2901
Diatomaceous Earth: Scanning Electron Microscope of ‘Chromosorb P’

EVERETT M. BENS
CHARLES M. DREW
Research01 Dec 1967
Nature

Volume: 216, P: 1046-1048
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

A multi-ancestry genome-wide association study meta-analysis, combined with transcriptome- and methylome-wide association analyses, identifies risk loci associated with colorectal cancer. Credible effector genes and their target tissues are also highlighted, showing that over a third probably act outside the colonic mucosa.

Ceres Fernandez-Rozadilla
Maria Timofeeva
Ulrike Peters
Research20 Dec 2022
Nature Genetics

Volume: 55, P: 89-99
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
Correction: Water-based non-stick hydrophobic coatings

Donald L. Schmidt
Charles E. Coburn
Daniel A. Fischer
Amendments and Corrections16 Jun 1994
Nature

Volume: 369, P: 584
Neurobilology: Molecular tinkerings that tailor the acetylcholine receptor

Charles F. Stevens
News & Views31 Jan 1985
Nature

Volume: 313, P: 350-351
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
Cryptic phosphoribosylase activity of NAMPT restricts the virion incorporation of viral proteins

The NAD⁺ synthesis enzyme NAMPT is shown to possess additional enzymatic activity as a phosphoribosylase, which restricts the virion incorporation of viral proteins and underpins its antiviral effect

Shu Feng
Na Xie
Pinghui Feng
Research21 Nov 2024
Nature Metabolism

Volume: 6, P: 2300-2318
Formation and inactivation of endogenous cannabinoid anandamide in central neurons

Vincenzo Di Marzo
Angelo Fontana
Danlele Piomelli
Research15 Dec 1994
Nature

Volume: 372, P: 686-691
Mechanisms in Early and Late Phases of Tolerance induced by Parabiosis in Adult Mice

N. W. NISBET
Research01 Jan 1968
Nature

Volume: 217, P: 265-267
DNA supercoiling and environmental regulation of virulence gene expression in Shigella flexneri

Charles J. Dorman
Niamh Ni Bhriain
Christopher F. Higgins
Research19 Apr 1990
Nature

Volume: 344, P: 789-792
Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells

Marc Bonneville
Charles A. Janeway Jr
Susumu Tonegawa
Research01 Dec 1988
Nature

Volume: 336, P: 479-481
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
KidneyGenAfrica, a pan-African partnership to deliver research and training excellence in genomics of kidney disease

Despite Africa’s vast genetic diversity, its populations are underrepresented in global genomic datasets. Here we describe the vision of the KidneyGenAfrica, a pan-African initiative launched to address this inequity, and call for more inclusive genomics research that recognizes Africa’s key role in genetic variation and potential to generate insights in chronic kidney disease.

Segun Fatumo
Oyesola Ojewunmi
June Fabian
Comments & Opinion20 Aug 2025
Nature Genetics

Volume: 57, P: 2079-2082
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

Raising cellular levels of the metabolic cofactor NAD⁺ reverses key indicators of aging. Here, Ratajczak et al. show that cellular levels of NAD⁺ depend on the extracellular catalytic activity of NRK1, which processes two NAD⁺precursors, nicotinamide mononucleotide and nicotinamide riboside, in mice.

Joanna Ratajczak
Magali Joffraud
Carles Cantó
ResearchOpen Access11 Oct 2016
Nature Communications

Volume: 7, P: 1-12
Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2

Denise G. O’Mahony
Susan J. Ramus
Elizabeth Santana dos Santos
ResearchOpen Access19 Apr 2023
British Journal of Cancer

Volume: 128, P: 2283-2294

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