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High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

Telomerase reverse-trancriptase promoter mutations have been recently found in human melanomas. Here, Nault et al.identify telomerase reverse-trancriptase promoter mutations as the most frequent somatic genetic alterations in hepatocellular carcinomas and as the first mutation identified in cirrhotic preneoplastic lesions.

Jean Charles Nault
Maxime Mallet
Jessica Zucman-Rossi
ResearchOpen Access26 Jul 2013
Nature Communications

Volume: 4, P: 1-7
Correction: Corrigendum: High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

Jean Charles Nault
Maxime Mallet
Jessica Zucman-Rossi
Amendments and Corrections10 Oct 2013
Nature Communications

Volume: 4, P: 1
Optical microresonators as single-particle absorption spectrometers

Single-particle double-modulation absorption spectrometers based on whispering-gallery-mode microresonators achieve sub-100-Hz sensitivity to photothermal resonance shifts and allow for the study of arrays of Fano resonances in the context of plasmonic–photonic hybridization.

Kevin D. Heylman
Niket Thakkar
Randall H. Goldsmith
Research07 Nov 2016
Nature Photonics

Volume: 10, P: 788-795
Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress

Cyclins A2 and E1 are known to regulate the cell cycle by promoting S phase entry and progression. Here, they identify an aggressive hepatocellular carcinoma subgroup exhibiting cyclin activation through various mechanisms and find this subgroup to display replication stress-induced structural rearrangements frequently activating TERT promoter.

Quentin Bayard
Léa Meunier
Eric Letouzé
ResearchOpen Access07 Dec 2018
Nature Communications

Volume: 9, P: 1-14
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

Jessica Zucman-Rossi and colleagues report exome sequences of 243 hepatocellular carcinomas. They identify mutational signatures associated with specific risk factors such as alcohol, tobacco and aflatoxin B1 and find genetic alterations potentially targetable by FDA-approved drugs in 28% of the tumors.

Kornelius Schulze
Sandrine Imbeaud
Jessica Zucman-Rossi
Research30 Mar 2015
Nature Genetics

Volume: 47, P: 505-511
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

Jessica Zucman-Rossi and colleagues report exome sequencing of 24 hepatocellular carcinomas and non-tumor liver tissues and copy-number analysis of 125 tumors. They identify new recurrent mutations in ARID1A, RPS6KA3, NFE2L2 and IRF2 in HCC.

Cécile Guichard
Giuliana Amaddeo
Jessica Zucman-Rossi
Research06 May 2012
Nature Genetics

Volume: 44, P: 694-698

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High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

Correction: Corrigendum: High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

Optical microresonators as single-particle absorption spectrometers

Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

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