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Showing 1–11 of 11 results

Advanced filters: Author: Charlotte Pawlyn Clear advanced filters

Immunotherapy using CAR T cells shows promising long-term outcomes for people with the blood cancer myeloma

A clinical trial reports data from one of the first groups of people with the blood cancer myeloma to receive a type of immunotherapy called CAR T cells.

Sarah Bird
Charlotte Pawlyn
News & Views19 Aug 2025
Nature

Volume: 645, P: 44-45
Evolutionary biology of high-risk multiple myeloma

Understanding how high-risk multiple myeloma evolves from more therapeutically tractable stages is crucial for improving outcomes for patients. This Review discusses the evolution of high-risk disease, how it may be diagnosed and how this might improve treatment.

Charlotte Pawlyn
Gareth J. Morgan
Reviews24 Aug 2017
Nature Reviews Cancer

Volume: 17, P: 543-556
Loss of heterozygosity as a marker of homologous repair deficiency in multiple myeloma: a role for PARP inhibition?

Charlotte Pawlyn
Andrea Loehr
Gareth J. Morgan
ResearchOpen Access02 Feb 2018
Leukemia

Volume: 32, P: 1561-1566
Whole body MRI by MY-RADS for imaging response assessment in multiple myeloma

Christina Messiou
Nuria Porta
Martin F. Kaiser
ResearchOpen Access17 Jul 2025
Blood Cancer Journal

Volume: 15, P: 1-8
APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma

Rearrangements of the Ig loci are essential for generating antibody diversity but abnormal translocations can be a driving event for myeloma. Here Walker et al. perform whole exome sequencing on myeloma patients to capture the diversity of mutational changes.

Brian A. Walker
Christopher P. Wardell
Gareth J. Morgan
Research23 Apr 2015
Nature Communications

Volume: 6, P: 1-11
The relative importance of factors predicting outcome for myeloma patients at different ages: results from 3894 patients in the Myeloma XI trial

Charlotte Pawlyn
David Cairns
Faith Davies
ResearchOpen Access14 Oct 2019
Leukemia

Volume: 34, P: 604-612
Mutations in CRBN and other cereblon pathway genes are infrequently associated with acquired resistance to immunomodulatory drugs

J. R. Jones
A. Barber
C. Pawlyn
ResearchOpen Access09 Aug 2021
Leukemia

Volume: 35, P: 3017-3020
Progression-free survival as a surrogate endpoint in myeloma clinical trials: an evolving paradigm

Charlotte Pawlyn
Fredrik H. Schjesvold
Paul G. Richardson
ReviewsOpen Access12 Aug 2024
Blood Cancer Journal

Volume: 14, P: 1-8
The prevalence and outcomes of frail older adults in clinical trials in multiple myeloma: A systematic review

Hira Mian
Arleigh McCurdy
Tanya M. Wildes
ResearchOpen Access05 Jan 2023
Blood Cancer Journal

Volume: 13, P: 1-13
Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control

C Pawlyn
M D Bright
F E Davies
ResearchOpen Access31 Mar 2017
Blood Cancer Journal

Volume: 7, P: e549
Recommendations for vaccination in multiple myeloma: a consensus of the European Myeloma Network

Heinz Ludwig
Mario Boccadoro
Pieter Sonneveld
ReviewsOpen Access19 Aug 2020
Leukemia

Volume: 35, P: 31-44