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Showing 1–11 of 11 results
Advanced filters: Author: Charlotte Unger Clear advanced filters
  • ATF6α activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming and local immunosuppression.

    • Xin Li
    • Cynthia Lebeaupin
    • Mathias Heikenwälder
    ResearchOpen Access
    Nature
    P: 1-12
  • Diagnostic blood-based biomarkers of pediatric IBD are limited. Here, the authors demonstrate a diagnostic lipidomic signature, comprising only of two molecular lipids. Translation of this signature into a scalable test has the potential to support clinical decision making.

    • Samira Salihovic
    • Niklas Nyström
    • Jonas Halfvarson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15
  • Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3 blockade.

    • Shaima’a Hamarsheh
    • Lena Osswald
    • Robert Zeiser
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17
  • The USA and the EU proposed a ‘Global Arrangement on Sustainable Steel and Aluminum (GASSA)’ as the first step towards a carbon club for clean steel in 2021. Yet, visions about the core elements of GASSA, a common standard for green steel and a tariff on ‘dirty’ steel, remain far apart. This comment discusses the international developments, domestic priorities, and structural conditions that enable and constrain the negotiations on GASSA. Ultimately, we argue that if the USA and the EU at least conclude an agreement with a definition for green steel and provide an opportunity for including further partners, this initiative might become a valuable endeavor for industrial decarbonization.

    • Charlotte Unger
    • Rainer Quitzow
    Comments & OpinionOpen Access
    npj Climate Action
    Volume: 3, P: 1-3
  • The evolving landscape of environmental, climate, and energy policy is marked by both pressing global challenges as well as opportunities for transformative action. Here, we discuss emerging debates and explore key themes in this dynamic field. We identify five key research strands that enhance climate change understanding and guide sustainable policymaking: actor dynamics, policy-science-society interface, stakeholder participation, global environmental cooperation, and environmental justice. A central question arises: How can we better reconcile the low-carbon transition with challenges such as climate justice, stakeholder collaboration, and cultural dimensions in policy formulation? We argue that the answer must lie in the application of a more wholesome vision of policymaking processes that focuses on the interconnectedness of these themes and emphasizes the need for integrated solutions, transdisciplinary collaboration, innovation, and inclusive governance to address complex environmental challenges. Our aim here is to deepen our understanding of environmental policy research’s complexities and future directions. We make the case for a concerted effort from policymakers, scholars, and stakeholders to navigate toward a more sustainable and equitable future.

    • Fateh Belaïd
    • Charlotte Unger
    Comments & OpinionOpen Access
    Humanities and Social Sciences Communications
    Volume: 11, P: 1-5