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Showing 1–14 of 14 results
Advanced filters: Author: Chen Davidovich Clear advanced filters

  • MORC2, a chromatin remodeler involved in epigenetic silencing and DNA repair, is linked to cancer and neurological disorders when dysregulated. Here, the authors show that MORC2 binds DNA at multiple sites, clamps onto it, and induces compaction, a process regulated by its phosphorylation.

    • Winnie Tan
    • Jeongveen Park
    • Shabih Shakeel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22

  • Here the authors show that a gene-inactivating protein complex packs inactive genes into a dynamic and accessible structure. The study challenges the traditional views that restricted accessibility and low dynamics cause gene repression.

    • Michael Uckelmann
    • Vita Levina
    • Chen Davidovich
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 520-530

  • A protein complex called the rixosome helps to degrade RNA transcripts that linger after gene expression ceases. This discovery points to distinct roles for the rixosome in regulating chromatin in different species.

    • Michael Uckelmann
    • Chen Davidovich
    News & Views
    Nature
    Volume: 604, P: 41-42

  • The polycomb repressive complex 2 (PRC2) is a histone methyltransferase regulating cell differentiation and identity. Here, the authors show that the vertebrate-specific PRC2 accessory subunit PALI1 facilitates substrate binding by the complex and elucidate the allosteric mechanism of PALI1- mediated PRC2 activation.

    • Qi Zhang
    • Samuel C. Agius
    • Chen Davidovich
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • In vivo and in vitro protein-RNA interaction maps identify an RNA-binding patch within the allosteric regulatory site of PRC2 that explains how RNA-mediated inhibition of PRC2 is relieved by allosteric activation.

    • Qi Zhang
    • Nicholas J. McKenzie
    • Chen Davidovich
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 237-247

  • Here the authors develop CRISPR–ChIP to enable the identification of factors required for chromatin regulation. Using this new method, they unveil a functional partitioning of H3K79 methylation into two distinct regulatory units, with important implications in MLL leukemia.

    • Omer Gilan
    • Laure Talarmain
    • Mark A. Dawson
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 1592-1606

  • Ubiquitination of histone H2A can occur on distinct lysine residues, but how each site is recognised by the specific E3 ligase remains poorly understood. Here the authors demonstrate that the E3 ligase RNF168 binds the acidic patch on the nucleosome surface, directing the E2 to the target lysine K13/K15.

    • Velten Horn
    • Michael Uckelmann
    • Hugo van Ingen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Getting safe and fast access to blood vessels is vital to many methods of treatment and diagnosis in medicine. Robot-assisted or even fully autonomous methods can potentially do the task more reliably than humans, especially when veins are hard to detect. In this work, a method is tested that uses deep learning to find blood vessels and track the movement of a patient’s arm.

    • Alvin I. Chen
    • Max L. Balter
    • Martin L. Yarmush
    Research
    Nature Machine Intelligence
    Volume: 2, P: 104-115

  • Polycomb repressive complex 2 (PRC2) is a histone methyltransferase required for epigenetic silencing during development and cancer, and it can be recruited to chromatin by long noncoding RNAs. In vitro binding studies and comparative analysis of genome-wide in vivo data now suggest a model for the maintenance of the repressed chromatin state by PRC2, directed by PRC2's promiscuous binding to nascent RNA transcripts.

    • Chen Davidovich
    • Leon Zheng
    • Thomas R Cech
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1250-1257