It is 40 years since the microtubule-associated protein tau was isolated and characterized, and 30 years since this protein was discovered to be abnormally hyperphoshorylated in the brains of patients with Alzheimer disease. To mark these important milestones, Iqbal and colleagues provide an overview of the pivotal discoveries in the tau research field over the past 40 years. They also review the current status of the field, focusing on the molecular biological insights that have established a key role for tau pathology in neurodegenerative disease, and the new therapeutic approaches that are emerging from this research.
- Khalid Iqbal
- Fei Liu
- Cheng-Xin Gong
