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Identification of multiple genomic alterations and prediction of neoantigens from circulating tumor cells at the single-cell level

This study introduces Uni-C, a single-cell method to map chromatin structure and genomic alterations in circulating tumor cells, enabling detection of genomic variants and neoantigen prediction to advance early diagnosis and therapeutic strategies.

Xiaochen Gao
Xinyu Li
Da Lin
ResearchOpen Access26 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants

Diosgenin is a spiroketal natural product that is used as a precursor in the industrial synthesis of steroids. Here, the authors identified key cytochrome P450 enzymes responsible for the conversion of cholesterol to diosgenin from two phylogenetical distinct diosgenin-producing plant species.

Bastien Christ
Chengchao Xu
Jing-Ke Weng
ResearchOpen Access19 Jul 2019
Nature Communications

Volume: 10, P: 1-11
Over-the-counter hearing aids reduce depression symptoms in older adults with hearing loss: a randomized controlled trial

In this randomized controlled trial, the authors investigate the benefits of over-the-counter hearing aids on depression symptoms in older adults with mild–moderate hearing loss.

Fan Jiang
Alimu Dayimu
Lei Xu
Research01 Apr 2025
Nature Mental Health

Volume: 3, P: 498-506
The spatiotemporal transcriptional profiling of murine brain during cerebral malaria progression and after artemisinin treatment

By integrating single-cell and spatial transcriptomic analysis, Chen et al. profile the cellular disruptions in the murine brain during cerebral malaria and after artemisinin treatment.

Jiayun Chen
Yunmeng Bai
Jigang Wang
ResearchOpen Access11 Feb 2025
Nature Communications

Volume: 16, P: 1-21
Predictors of one-year clinically driven revascularization following endovascular treatment of isolated atherosclerotic popliteal artery lesions

Zhiyong Dong
Lianrui Guo
Yongquan Gu
ResearchOpen Access25 Aug 2025
Scientific Reports

Volume: 15, P: 1-11
Spatial multi-omics at subcellular resolution via high-throughput in situ pairwise sequencing

A spatial multi-omics method with high decoding capacity and reduced sequencing and imaging costs enhances the high-throughput detection of gene mutations, allele-specific expression and RNA modifications in tissue samples.

Xiaofeng Wu
Weize Xu
Gang Cao
Research14 May 2024
Nature Biomedical Engineering

Volume: 8, P: 872-889
N-glycosylation of SnRK2s affects NADPH maintenance in peroxisomes during prolonged ABA signalling

During prolonged ABA signalling, N-glycosylation-mediated nucleus-peroxisome subcellular dynamics of SnRK2s orchestrate a transition state from short-term sensitive response to long-term acclimation to environmental stress.

Junyao Lu
Ning Li
Guodong Yang
ResearchOpen Access05 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Decoding the spatial chromatin organization and dynamic epigenetic landscapes of macrophage cells during differentiation and immune activation

Here the authors delineate the dynamic changes in 3D genome and epigenome of differentiating macrophages and during infection with Mycobacterium tuberculosis. They reveal a role for NF-κB upon infection and identify SNPs in disease-susceptible loci, including rs1873613 that is located in the anchor of a dynamic chromatin loop.

Da Lin
Weize Xu
Gang Cao
ResearchOpen Access04 Oct 2022
Nature Communications

Volume: 13, P: 1-19
Cholesterol modulates the physiological response to nanoparticles by changing the composition of protein corona

Here the authors report that the metabolome profile is an unexploited factor impacting the targeting efficacy and safety of nanomedicines, using cholesterol as an example, showing a way and need to develop personalized nanomedicines by harnessing disease-related metabolites.

Huan Tang
Ying Zhang
Jigang Wang
Research03 Aug 2023
Nature Nanotechnology

Volume: 18, P: 1067-1077
Female Breast Cancer Mortality Clusters in Shandong Province, China: A Spatial Analysis

Jie Chu
Chengchao Zhou
Aiqiang Xu
ResearchOpen Access07 Mar 2017
Scientific Reports

Volume: 7, P: 1-8
Glycosylation-directed quality control of protein folding

Membrane and soluble secretory proteins are glycosylated in the endoplasmic reticulum. The addition ofN-linked glycans is important for protein folding and quality control, whereas O-linked mannoses have distinct functions in protein quality control. Recent studies have revealed the complexity of these glycan-directed modifications in protein biogenesis and degradation.

Chengchao Xu
Davis T. W. Ng
Reviews14 Oct 2015
Nature Reviews Molecular Cell Biology

Volume: 16, P: 742-752
An algorithm for lane detection based on RIME optimization and optimal threshold

Shuang Zhai
Xiao Zhao
Chao Cheng
ResearchOpen Access08 Nov 2024
Scientific Reports

Volume: 14, P: 1-19
Bias sputtering of granular L1₀-FePt films with hexagonal boron nitride grain boundaries

Chengchao Xu
B. S. D. Ch. S. Varaprasad
Jian-Gang Zhu
ResearchOpen Access08 Jul 2023
Scientific Reports

Volume: 13, P: 1-10

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