The so far reported enzyme mimics focus on the redox-active metal as a redox site, while the redox-inert metal as Lewis acid has so far not been reported. Here, the authors report efficient MxV2O5·nH2O peroxidase mimics with vanadium as redox site and alkaline-earth metal ion (M2+) as Lewis acid, where the peroxidase-mimicking activity shows a periodic change with the Lewis acidity of the metal.
