AlphaFold2 is a popular protein structure prediction tool, however, achieving high accuracy remains challenging for certain proteins that share fewer homologs with the database. Here, the authors develop a new version of the MULTICOM system to improve the multi-sequence alignment, structural template, model ranking, model refinement, and hence the accuracy of AlphaFold2 prediction.
- Jian Liu
- Zhiye Guo
- Jianlin Cheng
