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Showing 1–5 of 5 results
Advanced filters: Author: Chengzhang Fu Clear advanced filters

  • Pepstatins are potent inhibitors of aspartic proteases, featuring two statine residues crucial for target binding, however, their biosynthesis is elusive. Here, the authors discover and characterize an unconventional gene cluster responsible for pepstatin biosynthesis, and characterize the role of PepI, an F420H2-dependent oxidoreductase catalysing the tandem reduction of β-keto pepstatin intermediates.

    • Jingjun Mo
    • Asfandyar Sikandar
    • Chengzhang Fu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • The mechanisms behind the antibacterial activity of the natural product carolacton are unknown. Here, the authors show that carolacton is a potent inhibitor of FolD/MTHFD enzymes (involved in folate-dependent C1 metabolism in bacteria and humans) and inhibits the growth of cancer cell lines

    • Chengzhang Fu
    • Asfandyar Sikandar
    • Rolf Müller
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Platinum is the most active catalyst for the hydrogen evolution reaction, but the specific mechanism and the influence of the alkali metal cations remain elusive in alkaline media. Now, electrical transport spectroscopy, electrochemical impedance spectroscopy and ab initio molecular dynamics simulations are combined to elucidate the role of alkali metal cations for this reaction in alkaline electrolyte.

    • Aamir Hassan Shah
    • Zisheng Zhang
    • Xiangfeng Duan
    Research
    Nature Catalysis
    Volume: 5, P: 923-933