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Showing 1–2 of 2 results
Advanced filters: Author: Chenqiang Jia Clear advanced filters

  • CRISPR-Cas9 is widely used for genome engineering but structural data for the DNA cleavage step are still incomplete. Here, the authors present the cryo-EM structure of a ternary Cas9-sgRNA-target DNA complex, perform MD simulations and discuss implications for the Cas9 DNA cleavage mechanism.

    • Cong Huai
    • Gan Li
    • Qiang Huang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Despite its electron deficiency, boron can form multiple bonds with a variety of elements, but such bonds between boron and main-group metal elements are relatively rare. Here, the authors characterize boron–lead multiple bonds in PbB2O- and PbB3O2- produced by laser vaporization.

    • Wei-Jia Chen
    • Teng-Teng Chen
    • Lai-Sheng Wang
    ResearchOpen Access
    Communications Chemistry
    Volume: 5, P: 1-7