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Showing 1–4 of 4 results
Advanced filters: Author: Chi Fung Willis Chow Clear advanced filters

  • Insulin sensitivity declines with age via unclear mechanisms. Here, the authors show that the activity of membrane type 1 matrix metalloproteinase (MT1-MMP) is increased with ageing, leading to cleavage of the insulin receptor, and show that metabolic effects can be rescued by MT1-MMP inhibition in mice.

    • Xuanming Guo
    • Pallavi Asthana
    • Hoi Leong Xavier Wong
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • The GDF15–GFRAL axis is key for regulating energy homeostasis and body weight. Membrane-bound matrix metalloproteinase 14 is shown to negatively regulate GFRAL, whereas its downregulation protects against diet-induced obesity through increased GDF15 signaling.

    • Chi Fung Willis Chow
    • Xuanming Guo
    • Hoi Leong Xavier Wong
    Research
    Nature Metabolism
    Volume: 4, P: 203-212

  • Crowdsourcing condensate database and encyclopedia is a community-editable platform for verified biomolecular condensates and their protein constituents. It also provides an encyclopedia for the scientific terms used in condensate biology and a crowdsourcing web application.

    • Nadia Rostam
    • Soumyadeep Ghosh
    • Agnes Toth-Petroczy
    ResearchOpen Access
    Nature Methods
    Volume: 20, P: 673-676

  • Early life stress has been associated with the occurrence of gastrointestinal diseases later in life, but underlying mechanisms remain poorly understood. Here, Wong et al. show that early life stress leads to expansion of intestinal stem cells and their differentiation into serotonin-producing enterochromaffin cells through crosstalk between NGF and Wnt signalling pathways.

    • Hoi Leong Xavier Wong
    • Hong-yan Qin
    • Zhao-xiang Bian
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14