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Advanced filters: Author: Chi-Keung Wan Clear advanced filters

IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells

The proinflammatory cytokine interleukin-1ß (IL-1ß) plays an important role in host defence against pathogens. Here the authors report a non-canonical pathway for IL-1 ß production in conventional dendritic cells that is induced by IL-21 via STAT3-dependent mechanism.

Chi-Keung Wan
Peng Li
Warren J. Leonard
ResearchOpen Access13 Aug 2015
Nature Communications

Volume: 6, P: 1-12
Deep genomic characterization highlights complexities and prognostic markers of pediatric acute myeloid leukemia

A genomic analysis of 147 pediatric acute myeloid leukemia patients identifies extensive gene fusion events and mutations that expand our understanding of the genetic complexities of this cancer.

Chi-Keung Cheng
Yuk-Lin Yung
Margaret H. L. Ng
ResearchOpen Access31 Mar 2023
Communications Biology

Volume: 6, P: 1-16

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IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells

Deep genomic characterization highlights complexities and prognostic markers of pediatric acute myeloid leukemia

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