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Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe²⁺-binding

Hou-Fu Guo
Chi-Lin Tsai
Jonathan M. Kurie
Amendments and CorrectionsOpen Access10 Jul 2018
Nature Communications

Volume: 9, P: 1
Molecular architecture and functional dynamics of the pre-incision complex in nucleotide excision repair

This study unveils the structure, dynamics, and regulatory mechanisms of a key nucleotide excision repair intermediate—the pre-incision complex (PInC). The PInC structural model links positions of disease mutations to genetic disease phenotypes.

Jina Yu
Chunli Yan
Ivaylo Ivanov
ResearchOpen Access01 Oct 2024
Nature Communications

Volume: 15, P: 1-15
Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases

The study unveils the structure, dynamics and regulatory mechanisms of the TFIIH protein assembly underpinning its divergent functions in gene expression and genome maintenance. Models link positions of TFIIH mutations to genetic disease phenotypes.

Jina Yu
Chunli Yan
Ivaylo Ivanov
ResearchOpen Access13 May 2023
Nature Communications

Volume: 14, P: 1-15
Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer

Polo-like kinase 3 (Plk3) has a tumor suppressive role through the induction of apoptosis, however, the mechanism underlying its activation is unclear. Here, in pancreatic cancer, the authors show that activation of Plk3 is dependent on its cleavage into p41Plk3, by the metalloendopeptidase nardilysin.

Jie Fu
Jianhua Ling
Paul J. Chiao
ResearchOpen Access11 Apr 2024
Nature Communications

Volume: 15, P: 1-19
The structure of the periplasmic FlaG–FlaF complex and its essential role for archaellar swimming motility

The structure of the FlaG–FlaF complexes from Sulfolobus acidocaldarius, combined with mutational and biochemical studies, suggests that these proteins form a heterotetrameric complex in which FlaF regulates the filamentation of FlaG and anchoring of the archaellum to the S-layer, thereby modulating motility.

Chi-Lin Tsai
Patrick Tripp
Sonja-Verena Albers
Research16 Dec 2019
Nature Microbiology

Volume: 5, P: 216-225
Probing water micro-solvation in proteins by water catalysed proton-transfer tautomerism

Detailed knowledge of the water environment within proteins may lead to an increased understanding of protein folding and function. Here the authors present a tryptophan analogue with remarkable water catalysed proton-transfer properties that may be exploited for site-specific water sensing.

Jiun-Yi Shen
Wei-Chih Chao
Pi-Tai Chou
Research01 Nov 2013
Nature Communications

Volume: 4, P: 1-7
Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe²⁺-binding

Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collagen cross-linking and metastasis.

Hou-Fu Guo
Chi-Lin Tsai
Jonathan M. Kurie
ResearchOpen Access06 Feb 2018
Nature Communications

Volume: 9, P: 1-9
A collagen glucosyltransferase drives lung adenocarcinoma progression in mice

Guo et al. determine the molecular basis of collagen lysyl hydroxylase 2 (LH2) substrate specificity. They further show that LH2 also functions as a collagen glucosyltransferase to promote lung cancer progression.

Hou-Fu Guo
Neus Bota-Rabassedas
Jonathan M. Kurie
ResearchOpen Access19 Apr 2021
Communications Biology

Volume: 4, P: 1-10

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