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Showing 1–2 of 2 results
Advanced filters: Author: Chi-Wei Yeh Clear advanced filters

  • Protein C-terminal diversity is widespread, yet its proteome-wide impact remains unclear. Here, the authors show that C-terminal variations influence the stability of canonical and disease associated mutant proteins and define the sequence features and degradative mechanisms underlying this regulation.

    • Ching-Yu Chu
    • Shu-Yu Hsu
    • Hsueh-Chi S. Yen
    ResearchOpen Access
    Nature Communications
    P: 1-14

  • Understanding assembly processes of protein complexes is crucial. The authors have developed a method to deduce protein complex assembly paths in living cells, revealing that the altered assembly pathways of paralogous complexes enable neo-functionalization and mitigate cross-complex interference.

    • Chi-Wei Yeh
    • Kuan-Lun Hsu
    • Hsueh-Chi S. Yen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18