Nature Search

A single-cell and spatially resolved atlas of human breast cancers

A multi-omic atlas of breast cancers, integrating single-cell RNA sequencing, spatial transcriptomics and immunophenotyping, identifies nine ecotypes associated with cellular heterogeneity and prognosis.

Sunny Z. Wu
Ghamdan Al-Eryani
Alexander Swarbrick
Research06 Sept 2021
Nature Genetics

Volume: 53, P: 1334-1347
A village in a dish model system for population-scale hiPSC studies

Village cultures, where multiple stem cell lines are cultured in a single dish, provide an elegant solution for population-scale studies. Here, authors show the utility of village models – showing that expression heterogeneity is largely a result of line-specific effects and not village cultures.

Drew R. Neavin
Angela M. Steinmann
Joseph E. Powell
ResearchOpen Access09 Jun 2023
Nature Communications

Volume: 14, P: 1-12
Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits

Genome-wide association study of cerebrospinal fluid and brain metabolites highlights the unique genetic architecture of metabolite levels and metabolite–trait associations with brain-related phenotypes.

Ciyang Wang
Chengran Yang
Carlos Cruchaga
Research11 Nov 2024
Nature Genetics

Volume: 56, P: 2685-2695
Empiric embolization by vasospasm therapy for acute lower gastrointestinal bleeding: a preliminary report

Huei-Lung Liang
Chia-Ling Chiang
Ming-Feng Li
ResearchOpen Access28 Oct 2024
Scientific Reports

Volume: 14, P: 1-9
DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and immunotherapy response

Understanding the molecular mechanisms of cancer immunoediting could provide insight into resistance to immunotherapy. Here, DNA barcoding provides evidence of ongoing immunoediting during metastasis and treatment with anti-PD1 and anti-CTLA4, and identifies cancer cell clones with unique immune evasive phenotypes.

Louise A. Baldwin
Nenad Bartonicek
Simon Junankar
ResearchOpen Access07 Nov 2022
Nature Communications

Volume: 13, P: 1-18
Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration

Age-related macular degeneration (AMD) is a leading cause of vision loss, and there is no approved treatment for AMD with geographic atrophy. Here, the authors used transcriptomic and proteomic analyses of patient induced pluripotent stem cell-derived retinal pigment epithelium to better understand disease mechanisms.

Anne Senabouth
Maciej Daniszewski
Alice Pébay
ResearchOpen Access26 Jul 2022
Nature Communications

Volume: 13, P: 1-18
Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

Stromal cell recruitment, activation and crosstalk with cancer cells is poorly understood. Here, the authors demonstrate that cancer cell-derived Hedgehog ligand triggers stromal remodeling that in turn induces a cancer-stem-cell like, drug-resistant phenotype of nearby cancer cells while treatment with smoothened inhibitors reverses these phenotypes.

Aurélie S. Cazet
Mun N. Hui
Alexander Swarbrick
ResearchOpen Access24 Jul 2018
Nature Communications

Volume: 9, P: 1-18
Cartilage oligomeric matrix protein overexpression is an independent poor prognostic indicator in patients with intrahepatic cholangiocarcinoma

Khaa Hoo Ong
Yao-Yu Hsieh
Yu-Hsuan Kuo
ResearchOpen Access14 Oct 2023
Scientific Reports

Volume: 13, P: 1-11
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

This Perspective lays out the impetus and goals of the Cellular Senescence Network established to comprehensively identify and characterize senescent cells (SnCs) across tissues and lifespan, providing a publicly available SnC atlas.

Patty J. Lee
Christopher C. Benz
Mingyu Yang
Reviews20 Dec 2022
Nature Aging

Volume: 2, P: 1090-1100
Utilisation of Oxford Nanopore sequencing to generate six complete gastropod mitochondrial genomes as part of a biodiversity curriculum

Mattia De Vivo
Hsin-Han Lee
Isheng Jason Tsai
ResearchOpen Access15 Jun 2022
Scientific Reports

Volume: 12, P: 1-11
Development and validation of a targeted gene sequencing panel for application to disparate cancers

Mark J. McCabe
Marie-Emilie A. Gauthier
Mary-Anne Young
ResearchOpen Access19 Nov 2019
Scientific Reports

Volume: 9, P: 1-16
MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer

Hui-Ming Lin
Iva Nikolic
Alexander Swarbrick
ResearchOpen Access18 May 2018
Scientific Reports

Volume: 8, P: 1-12
Tumor inherent interferon regulators as biomarkers of long-term chemotherapeutic response in TNBC

Natasha K. Brockwell
Jai Rautela
Belinda S. Parker
ResearchOpen Access29 Aug 2019
npj Precision Oncology

Volume: 3, P: 1-13

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