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Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells

PI3Kδ controls the expression of the recombinogenic enzyme AID; excessive AID activity caused by PI3Kδ inhibition can induce genomic instability in leukaemia and lymphoma cells, as well as in patients with chronic lymphocytic leukaemia treated with PI3Kδ inhibitors.

Mara Compagno
Qi Wang
Roberto Chiarle
Research15 Feb 2017
Nature

Volume: 542, P: 489-493
Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma

WASP is a novel tumor-suppressor gene in ALK-driven anaplastic large cell lymphoma through modulation of CDC42 and MAPK signaling and provides a rationale for combination therapy.

Matteo Menotti
Chiara Ambrogio
Roberto Chiarle
Research03 Dec 2018
Nature Medicine

Volume: 25, P: 130-140
Early inflammation as a footprint of increased mortality risk in infants living with HIV from three African countries

Elena Morrocchi
Giuseppe R. Pascucci
Cissy Kityo
ResearchOpen Access28 Oct 2024
Scientific Reports

Volume: 14, P: 1-11
Distinct pro-inflammatory/pro-angiogenetic signatures distinguish children with Long COVID from controls

Danilo Buonsenso
Nicola Cotugno
Paolo Palma
Research24 Jan 2025
Pediatric Research

Volume: 98, P: 928-935
Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition

Sara Petillo
Cristina Capuano
Marco Cippitelli
ResearchOpen Access04 Sept 2021
Cell Death & Disease

Volume: 12, P: 1-13