Nature Search

Maternal control of triploid seed development by the TRANSPARENT TESTA 8 (TT8) transcription factor in Arabidopsis thaliana

Cecilia Zumajo-Cardona
Manuel Aguirre
Ignacio Ezquer
ResearchOpen Access24 Jan 2023
Scientific Reports

Volume: 13, P: 1-12
Chloroplast and whole-genome sequencing shed light on the evolutionary history and phenotypic diversification of peanuts

Chloroplast and whole-genome sequencing of a global germplasm panel of 355 Arachis accessions encompassing various species sheds light on the evolutionary history and phenotypic diversification of peanuts.

Zheng Zheng
Ziqi Sun
Xinyou Zhang
ResearchOpen Access13 Aug 2024
Nature Genetics

Volume: 56, P: 1975-1984
TTG1 proteins regulate circadian activity as well as epidermal cell fate and pigmentation

Subfunctionalization allows gene paralogues to perform distinct ancestral functions. Now, Glover et al. report the functional divergence of proteins of the TRANSPARENT TESTA GLABRA 1 (TTG1) WD40-repeat family in Arabidopsis, showing that small changes in highly conserved proteins can result in major changes to their functions.

Chiara A. Airoldi
Timothy J. Hearn
Beverley J. Glover
Research11 Nov 2019
Nature Plants

Volume: 5, P: 1145-1153
Un robot che cresce e riproduce il comportamento delle piante rampicanti

Un gruppo di ricerca ha messo a punto un robot simile a una pianta di vite che cresce attraverso la stampa 3D in risposta a gravità e luce.

Chiara Sabelli
News25 Jan 2024
Nature Italy
Un nuovo sensore per terapie anticancro più precise

Uno studio descrive un dispositivo organico e flessibile che può inserirsi nel corpo di un paziente e misurare le radiazioni rilasciate dalla terapia adronica.

Chiara Sabelli
Research Highlights23 Apr 2021
Nature Italy
Il long COVID è meno diffuso nelle popolazioni più vaccinate

Un metodo statistico sviluppato da uno scienziato italiano ha permesso di misurare la prevalenza della sindrome, e come è influenzata dalle percentuali di vaccinazione.

Chiara Sabelli
Research Highlights16 Jul 2023
Nature Italy
Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ

The role of epigenetic deregulation in colorectal cancer (CRC) is not fully understood yet. Here the authors use patient-derived organoids, epigenomics and single-cell RNA-seq to reveal that YAP/TAZ are key regulators that bind to active enhancers in CRC and promote tumour survival.

Giulia Della Chiara
Federica Gervasoni
Massimiliano Pagani
ResearchOpen Access20 Apr 2021
Nature Communications

Volume: 12, P: 1-18
Event-triggered STED imaging

Event-triggered STED is an automated approach that can initiate 2D or 3D STED imaging of specific regions in biological samples after detection of an event of interest. This approach can help maximize observations in live cell imaging and enable discovery.

Jonatan Alvelid
Martina Damenti
Ilaria Testa
ResearchOpen Access08 Sept 2022
Nature Methods

Volume: 19, P: 1268-1275
Targeted protein degradation via intramolecular bivalent glues

Studies using genetic screening, biophysical characterization and structural reconstitution elucidate the mechanism of action and enable rational design of a new class of functional compounds that glue target proteins to E3 ligases via intramolecularly bridging two domains to enhance intrinsic protein–protein interactions and promote target ubiquitination and degradation.

Oliver Hsia
Matthias Hinterndorfer
Alessio Ciulli
ResearchOpen Access21 Feb 2024
Nature

Volume: 627, P: 204-211
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

tag-Targeted Protein Degrader (tTPD) systems are powerful tools for preclinical target validation. Here the authors extend the tTPD platform by developing NanoTACs that degrade NanoLuc tagged substrates and benchmark each tTPD system using an interchangeable tag reporter system.

Christoph Grohmann
Charlene M. Magtoto
Rebecca Feltham
ResearchOpen Access19 Apr 2022
Nature Communications

Volume: 13, P: 1-13
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Trivalent PROTACs are reported as a strategy to increase protein degradation efficacy and therapeutic window by combining avidity of target engagement with cooperativity to form highly favorable and productive ternary complexes.

Satomi Imaide
Kristin M. Riching
Alessio Ciulli
Research21 Oct 2021
Nature Chemical Biology

Volume: 17, P: 1157-1167
Comparative one-month safety and effectiveness of five leading new-generation devices for transcatheter aortic valve implantation

Arturo Giordano
Nicola Corcione
Fabrizio Tomai
ResearchOpen Access19 Nov 2019
Scientific Reports

Volume: 9, P: 1-12
Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes

Alberto Montesanto
Anna Rita Bonfigli
Giuseppina Rose
ResearchOpen Access17 Jul 2019
Scientific Reports

Volume: 9, P: 1-7
YY1 mutations disrupt corticogenesis through a cell type specific rewiring of cell-autonomous and non-cell-autonomous transcriptional programs

Marlene F. Pereira
Veronica Finazzi
Giuseppe Testa
ResearchOpen Access22 Feb 2025
Molecular Psychiatry

Volume: 30, P: 3413-3429
Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemness

Chiara Battistini
Hilary A. Kenny
Ugo Cavallaro
ResearchOpen Access28 May 2024
Cell Death & Disease

Volume: 15, P: 1-13
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Targeting the ubiquitin proteasome system to modulate protein homeostasis using small molecules has promising therapeutic potential. Here the authors describe Homo-PROTACS: small molecules that can induce the homo-dimerization of E3 ubiquitin ligases and cause their proteasome-dependent degradation.

Chiara Maniaci
Scott J. Hughes
Alessio Ciulli
ResearchOpen Access10 Oct 2017
Nature Communications

Volume: 8, P: 1-14
A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

PIN1 is a promising therapeutic target for cancer treatment. In this study, the authors identify a covalent inhibitor of PIN1 with anti-tumour and anti-metastatic properties thanks to PIN1 inactivation and to the release, after binding to PIN1, of a quinone-mimicking compound that elicits reactive oxygen generation and causes DNA damage.

Elena Campaner
Alessandra Rustighi
Giannino Del Sal
ResearchOpen Access09 Jun 2017
Nature Communications

Volume: 8, P: 1-15
Connectivity modulations induced by reach&grasp movements: a multidimensional approach

Pietro Caliandro
Gloria Menegaz
Silvia F. Storti
ResearchOpen Access29 Nov 2021
Scientific Reports

Volume: 11, P: 1-11
Comparison of the ADNEX and ROMA risk prediction models for the diagnosis of ovarian cancer: a multicentre external validation in patients who underwent surgery

Chiara Landolfo
Jolien Ceusters
Ben Van Calster
Research19 Jan 2024
British Journal of Cancer

Volume: 130, P: 934-940
Antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable Haemophilus influenzae

Marthe T. C. Walvoort
Chiara Testa
Anna Maria Papini
ResearchOpen Access23 Dec 2016
Scientific Reports

Volume: 6, P: 1-12
Upper limb joint kinematics using wearable magnetic and inertial measurement units: an anatomical calibration procedure based on bony landmark identification

Pietro Picerno
Pietro Caliandro
Andrea Cereatti
ResearchOpen Access08 Oct 2019
Scientific Reports

Volume: 9, P: 1-10
Author Correction: Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes

Alberto Montesanto
Anna Rita Bonfigli
Giuseppina Rose
Amendments and CorrectionsOpen Access21 Feb 2020
Scientific Reports

Volume: 10, P: 1
Erratum: Antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable Haemophilus influenzae

Marthe T. C. Walvoort
Chiara Testa
Anna Maria Papini
Amendments and CorrectionsOpen Access22 Mar 2017
Scientific Reports

Volume: 7, P: 1
Impaired Systolic and Diastolic Left Ventricular Function in Children with Chronic Kidney Disease - Results from the 4C Study

Anke Doyon
Pascal Haas
Franz Schaefer
ResearchOpen Access07 Aug 2019
Scientific Reports

Volume: 9, P: 1-9
Differential diagnosis of neurodegenerative dementias with the explainable MRI based machine learning algorithm MUQUBIA

Silvia De Francesco
Claudio Crema
Fabio Maria Triulzi
ResearchOpen Access13 Oct 2023
Scientific Reports

Volume: 13, P: 1-19
A machine-learning parsimonious multivariable predictive model of mortality risk in patients with Covid-19

Rita Murri
Jacopo Lenkowicz
Lorenzo Zileri Dal Verme
ResearchOpen Access27 Oct 2021
Scientific Reports

Volume: 11, P: 1-10
Shaping modern human skull through epigenetic, transcriptional and post-transcriptional regulation of the RUNX2 master bone gene

Lorena Di Pietro
Marta Barba
Wanda Lattanzi
ResearchOpen Access29 Oct 2021
Scientific Reports

Volume: 11, P: 1-15
Author Correction: Differential diagnosis of neurodegenerative dementias with the explainable MRI based machine learning algorithm MUQUBIA

Silvia De Francesco
Claudio Crema
Fabio Maria Triulzi
Amendments and CorrectionsOpen Access18 Jan 2024
Scientific Reports

Volume: 14, P: 1

Search

Maternal control of triploid seed development by the TRANSPARENT TESTA 8 (TT8) transcription factor in Arabidopsis thaliana

Chloroplast and whole-genome sequencing shed light on the evolutionary history and phenotypic diversification of peanuts

TTG1 proteins regulate circadian activity as well as epidermal cell fate and pigmentation

Un robot che cresce e riproduce il comportamento delle piante rampicanti

Un nuovo sensore per terapie anticancro più precise

Il long COVID è meno diffuso nelle popolazioni più vaccinate

Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ

Event-triggered STED imaging

Targeted protein degradation via intramolecular bivalent glues

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Comparative one-month safety and effectiveness of five leading new-generation devices for transcatheter aortic valve implantation

Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes

YY1 mutations disrupt corticogenesis through a cell type specific rewiring of cell-autonomous and non-cell-autonomous transcriptional programs

Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemness

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

Connectivity modulations induced by reach&grasp movements: a multidimensional approach

Comparison of the ADNEX and ROMA risk prediction models for the diagnosis of ovarian cancer: a multicentre external validation in patients who underwent surgery

Antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable Haemophilus influenzae

Upper limb joint kinematics using wearable magnetic and inertial measurement units: an anatomical calibration procedure based on bony landmark identification

Author Correction: Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes

Erratum: Antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable Haemophilus influenzae

Impaired Systolic and Diastolic Left Ventricular Function in Children with Chronic Kidney Disease - Results from the 4C Study

Differential diagnosis of neurodegenerative dementias with the explainable MRI based machine learning algorithm MUQUBIA

A machine-learning parsimonious multivariable predictive model of mortality risk in patients with Covid-19

Shaping modern human skull through epigenetic, transcriptional and post-transcriptional regulation of the RUNX2 master bone gene

Author Correction: Differential diagnosis of neurodegenerative dementias with the explainable MRI based machine learning algorithm MUQUBIA

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