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GeneAgent: self-verification language agent for gene-set analysis using domain databases

GeneAgent is a language agent using large language models and self-verification to improve gene-set function annotation.

Zhizheng Wang
Qiao Jin
Zhiyong Lu
ResearchOpen Access28 Jul 2025
Nature Methods

Volume: 22, P: 1677-1685
Tracking genetic variants in the biomedical literature using LitVar 2.0

Keeping up with the latest variant-related research is vital for genomic medicine. Here we present LitVar 2.0, a significantly improved web-based system to accurately search for genetic variants in the unstructured literature. LitVar 2.0 provides a unified search of full text and supplementary data, and improved variant recognition accuracy.

Alexis Allot
Chih-Hsuan Wei
Zhiyong Lu
Comments & Opinion02 Jun 2023
Nature Genetics

Volume: 55, P: 901-903
High-performance near-infrared OLEDs maximized at 925 nm and 1022 nm through interfacial energy transfer

The low photoluminescence quantum yield of near-infrared (NIR) emitters has limited their application in organic light-emitting diodes (OLEDs). Here, authors realize NIR OLEDs through interfacial energy transfer from platinum(II) complexes to a non-fullerene acceptor based on a sandwiched structure.

Chieh-Ming Hung
Sheng-Fu Wang
Pi-Tai Chou
ResearchOpen Access31 May 2024
Nature Communications

Volume: 15, P: 1-10
Synthesis, structural analysis, and properties of highly twisted alkenes 13,13’-bis(dibenzo[a,i]fluorenylidene) and its derivatives

The rotation of a carbon double bond in an alkene can be efficiently accelerated by creating the high strain ground state and stabilizing the transition state of the process. Here, the authors report the synthesis, structures, and properties of several highly twisted alkenes.

Hao-Wen Kang
Yu-Chiao Liu
Yao-Ting Wu
ResearchOpen Access28 Aug 2023
Nature Communications

Volume: 14, P: 1-10
Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

Chemodynamic therapy (CDT) uses Fenton chemistry to covert hydrogen peroxide in cancer cells to toxic hydroxyl radicals, but endogenous hydrogen peroxide is insufficient to drive sustainable CDT. Here, the authors report a water oxidation CoFe Prussian blue nanoframe to provide sustained, external energy free self-supply of hydroxyl radicals for CDT.

Liu-Chun Wang
Pei-Yu Chiou
Chen-Sheng Yeh
ResearchOpen Access05 Aug 2023
Nature Communications

Volume: 14, P: 1-16
Overcoming small-bandgap charge recombination in visible and NIR-light-driven hydrogen evolution by engineering the polymer photocatalyst structure

Designing an organic polymer photocatalyst for efficient hydrogen evolution in the near-infrared (NIR) light region is still a major challenge. The authors present here a series of polymer nanoparticles for a efficient hydrogen evolution under visible and NIR light irradiation, without combining or hybridizing with other materials.

Mohamed Hammad Elsayed
Mohamed Abdellah
Ho-Hsiu Chou
ResearchOpen Access24 Jan 2024
Nature Communications

Volume: 15, P: 1-13
WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour

The authors show that the Drosophila master regulator WAKE modulates the secretion of insulin-like peptides, triggering a decrease in 20-hydroxyecdysone levels. This lowers the perception of a male-specific sex pheromone and explains why WAKE-deficient Drosophila flies show male-male courtship behaviour.

Shiu-Ling Chen
Bo-Ting Liu
Tsai-Feng Fu
ResearchOpen Access06 May 2022
Nature Communications

Volume: 13, P: 1-18
Preclinical systolic dysfunction relating to ankle-brachial index among high-risk PAD population with preserved left ventricular ejection fraction

Yueh-Hung Lin
Kuo-Tzu Sung
Chung-Lieh Hung
ResearchOpen Access14 Mar 2024
Scientific Reports

Volume: 14, P: 1-12
MicroRNAs from Snellenius manilae bracovirus regulate innate and cellular immune responses of its host Spodoptera litura

Tang et al. show that microRNAs derived from an endoparasitic wasp Snellenius manilae bracovirus (SmBV), SmBV-miR-199b-5p and SmBV-miR-2989, target domeless and toll-7 in its host Spodoptera litura, suppressing the innate immune responses of parasitized hosts. This study provides insights into how parasites maximize their fitness by regulating host immunity.

Cheng-Kang Tang
Chih-Hsuan Tsai
Yueh-Lung Wu
ResearchOpen Access08 Jan 2021
Communications Biology

Volume: 4, P: 1-11
An essential role of acetyl coenzyme A in the catalytic cycle of insect arylalkylamine N-acetyltransferase

Wu et al. provide insight to the role of acetyl coenzyme A in regulating N-acetylation in insect AANAT using ITC and NMR methods. These results provide useful data on the structural function of insect AANATs.

Chu-Ya Wu
I-Chen Hu
Ping-Chiang Lyu
ResearchOpen Access14 Aug 2020
Communications Biology

Volume: 3, P: 1-12
EnzChemRED, a rich enzyme chemistry relation extraction dataset

Po-Ting Lai
Elisabeth Coudert
Alan Bridge
ResearchOpen Access09 Sept 2024
Scientific Data

Volume: 11, P: 1-19
NLM-Chem, a new resource for chemical entity recognition in PubMed full text literature

Rezarta Islamaj
Robert Leaman
Zhiyong Lu
ResearchOpen Access25 Mar 2021
Scientific Data

Volume: 8, P: 1-12

Search

GeneAgent: self-verification language agent for gene-set analysis using domain databases

Tracking genetic variants in the biomedical literature using LitVar 2.0

High-performance near-infrared OLEDs maximized at 925 nm and 1022 nm through interfacial energy transfer

Synthesis, structural analysis, and properties of highly twisted alkenes 13,13’-bis(dibenzo[a,i]fluorenylidene) and its derivatives

Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

Overcoming small-bandgap charge recombination in visible and NIR-light-driven hydrogen evolution by engineering the polymer photocatalyst structure

WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour

Preclinical systolic dysfunction relating to ankle-brachial index among high-risk PAD population with preserved left ventricular ejection fraction

MicroRNAs from Snellenius manilae bracovirus regulate innate and cellular immune responses of its host Spodoptera litura

An essential role of acetyl coenzyme A in the catalytic cycle of insect arylalkylamine N-acetyltransferase

EnzChemRED, a rich enzyme chemistry relation extraction dataset

NLM-Chem, a new resource for chemical entity recognition in PubMed full text literature

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