Nature Search

Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery

Extracellular vesicles (EVs) have shown potential as a therapeutic delivery system for cancer treatment. In here the authors have established HEK293T cells engineered with α-HLA-G VHH antibody-chimeric CD63 protein to promote the production of EVs that can augment the targeting of HLA-G-positive tumor cells

Ming-You Shie
Shi-Wei Huang
Der-Yang Cho
ResearchOpen Access13 Dec 2025
Nature Communications

Volume: 16, P: 1-16
Tacrolimus dosing in liver transplant recipients using phenotypic personalized medicine: A phase 2 randomized clinical trial

Tacrolimus is a critical immunosuppressant for liver transplant recipients, but its dosing is challenging due to individual variability. Here, the authors show that a phenotypic personalized medicine approach improves tacrolimus dosing precision, reducing large deviations from target levels and shortening hospital stays in a Phase 2 randomized trial.

Jeffrey Khong
Megan Lee
Ali Zarrinpar
ResearchOpen Access16 May 2025
Nature Communications

Volume: 16, P: 1-10
An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells

Stem cell-mediated regenerative medicine requires the development of defined culture systems for the maintenance of human embryonic stem cells. Here, feedback system control is used to identify a combination of three small molecule inhibitors that enables long-term human embryonic stem cell maintenance.

Hideaki Tsutsui
Bahram Valamehr
Hong Wu
Research25 Jan 2011
Nature Communications

Volume: 2, P: 1-8
In vitro reconstruction of branched tubular structures from lung epithelial cells in high cell concentration gradient environment

Masaya Hagiwara
Fei Peng
Chih-Ming Ho
ResearchOpen Access27 Jan 2015
Scientific Reports

Volume: 5, P: 1-7
Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time

Current antibiotic therapies for tuberculosis are lengthy and onerous. Here, the authors use an output-driven approach to optimize drug doses for two experimental drug regimens in a mouse model of tuberculosis, leading to improved regimens that reduce treatment time by 75%.

Bai-Yu Lee
Daniel L. Clemens
Marcus A. Horwitz
ResearchOpen Access24 Jan 2017
Nature Communications

Volume: 8, P: 1-11
Sympatric competitors have driven the evolution of temporal activity patterns in Cnemaspis geckos in Southeast Asia

Hung Ngoc Nguyen
Chih-Ming Hung
Si-Min Lin
ResearchOpen Access08 Jan 2020
Scientific Reports

Volume: 10, P: 1-8
Inhibition of Bruton’s tyrosine kinase as a therapeutic strategy for chemoresistant oral squamous cell carcinoma and potential suppression of cancer stemness

Shao-Cheng Liu
Yang-Che Wu
Chun-Shu Lin
ResearchOpen Access27 Feb 2021
Oncogenesis

Volume: 10, P: 1-18
Urinary neutrophil gelatinase-associated lipocalin is associated with heavy metal exposure in welding workers

Kai-Jen Chuang
Chih-Hong Pan
Hsiao-Chi Chuang
ResearchOpen Access17 Dec 2015
Scientific Reports

Volume: 5, P: 1-9
Compact Wireless Microscope for In-Situ Time Course Study of Large Scale Cell Dynamics within an Incubator

Di Jin
Dennis Wong
Peng Fei
ResearchOpen Access18 Dec 2015
Scientific Reports

Volume: 5, P: 1-12
A streamlined search technology for identification of synergistic drug combinations

Andrea Weiss
Robert H. Berndsen
Patrycja Nowak-Sliwinska
ResearchOpen Access29 Sept 2015
Scientific Reports

Volume: 5, P: 1-11
Guiding the osteogenic fate of mouse and human mesenchymal stem cells through feedback system control

Yoshitomo Honda
Xianting Ding
Ichiro Nishimura
ResearchOpen Access05 Dec 2013
Scientific Reports

Volume: 3, P: 1-9
Preclinical optimization of a broad-spectrum anti-bladder cancer tri-drug regimen via the Feedback System Control (FSC) platform

Qi Liu
Cheng Zhang
Jingde Zhu
ResearchOpen Access19 Jun 2015
Scientific Reports

Volume: 5, P: 1-17
Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function

Peng Fei
Juhyun Lee
Tzung K. Hsiai
ResearchOpen Access03 Mar 2016
Scientific Reports

Volume: 6, P: 1-12
Optimization of drug combinations using Feedback System Control

Nowak-Sliwinska et al. describe a protocol for optimizing drug combinations using Feedback System Control (FSC). Drug combinations are tested in a cell-based assay in which results are entered into the FSC pipeline to predict new combinations to be tested in vitro.

Patrycja Nowak-Sliwinska
Andrea Weiss
Chih-Ming Ho
Protocols14 Jan 2016
Nature Protocols

Volume: 11, P: 302-315
DNA Diagnostics: Nanotechnology-Enhanced Electrochemical Detection of Nucleic Acids

Fang Wei
Peter B Lillehoj
Chih-Ming Ho
Reviews01 May 2010
Pediatric Research

Volume: 67, P: 458-468

Search

Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery

Tacrolimus dosing in liver transplant recipients using phenotypic personalized medicine: A phase 2 randomized clinical trial

An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells

In vitro reconstruction of branched tubular structures from lung epithelial cells in high cell concentration gradient environment

Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time

Sympatric competitors have driven the evolution of temporal activity patterns in Cnemaspis geckos in Southeast Asia

Inhibition of Bruton’s tyrosine kinase as a therapeutic strategy for chemoresistant oral squamous cell carcinoma and potential suppression of cancer stemness

Urinary neutrophil gelatinase-associated lipocalin is associated with heavy metal exposure in welding workers

Compact Wireless Microscope for In-Situ Time Course Study of Large Scale Cell Dynamics within an Incubator

A streamlined search technology for identification of synergistic drug combinations

Guiding the osteogenic fate of mouse and human mesenchymal stem cells through feedback system control

Preclinical optimization of a broad-spectrum anti-bladder cancer tri-drug regimen via the Feedback System Control (FSC) platform

Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function

Optimization of drug combinations using Feedback System Control

DNA Diagnostics: Nanotechnology-Enhanced Electrochemical Detection of Nucleic Acids

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