Human interleukin-10 (IL-10) is known to be an immunosuppressive cytokine for anti-inflammation, however, IL-10 can enable the evasion of tumor cells through immunosuppression of the host immune system. Here, the authors develop an IL-10 inhibitory peptide, NK20a, that displays anticancer effects, and show that its conjugation with chemotherapeutic gold nanoparticles enhances their anticancer efficacy.
- Chun-Chun Chang
- Chin-Hao Yang
- Hao-Jen Hsu
