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Showing 1–3 of 3 results
Advanced filters: Author: Chin-Hsien Tai Clear advanced filters

  • PcdA interacts with DivIVA and FtsZ, promoting Z-ring formation and division plane selection in Staphylococcus aureus, which increases virulence in mice and reduces sensitivity to cell-wall-targeting antibiotics.

    • Félix Ramos-León
    • Brandon R. Anjuwon-Foster
    • Kumaran S. Ramamurthi
    Research
    Nature Microbiology
    Volume: 9, P: 2997-3012

  • Liu et al find that mesothelin (MSLN), a candidate target for antibody-based cancer therapy, is targeted by several proteases, and that inhibition of shedding facilitates killing of cells by an immunotoxin targeting MSLN.

    • Xiufen Liu
    • Alexander Chan
    • Ira Pastan
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-9

  • Chimeric antigen receptor T (CAR-T) cells represent an emerging form of immune therapy but success, especially in solid tumors, is limited by the scarcity of suitable target epitopes. Here authors show that a distinct epitope motif on the transmembrane protein B7-H3, recognized by a camel nanobody, triggers robust activation and anti-tumor function in cognate CAR-T cells.

    • Dan Li
    • Ruixue Wang
    • Mitchell Ho
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17