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Proteotoxic stress response drives T cell exhaustion and immune evasion

A proteotoxic stress response specific to exhausted T cells, governed by AKT signaling and accompanied by increased protein translation, represents a mechanistic vulnerability and a new therapeutic target to improve cancer immunotherapies.

Yi Wang
Anjun Ma
Zihai Li
ResearchOpen Access01 Oct 2025
Nature

P: 1-11
Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis

Adrian M Piliponsky
Ching-Cheng Chen
Stephen J Galli
Research30 Mar 2008
Nature Medicine

Volume: 14, P: 392-398
Endochondral ossification is required for haematopoietic stem-cell niche formation

This paper describes an in vivo assay of haematopoietic stem cell (HSC) niche formation. A population of progenitor cells is sorted from fetal bones, and when transplanted under the adult mouse kidney capsule, the cells recruit host-derived blood vessels, produce donor-derived ectopic bones, and generate a marrow cavity populated by host-derived long-term reconstituting haematopoeitic stem cells.

Charles K. F. Chan
Ching-Cheng Chen
Irving L. Weissman
Research10 Dec 2008
Nature

Volume: 457, P: 490-494
PERK is a critical metabolic hub for immunosuppressive function in macrophages

Raines et al. examine the role of the PERK-mediated ER stress response in promoting and sustaining M2-like macrophages in type 2 immune response and in tumor immunity.

Lydia N. Raines
Haoxin Zhao
Stanley Ching-Cheng Huang
Research28 Feb 2022
Nature Immunology

Volume: 23, P: 431-445
Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche

How the environment of the niche regulates haematopoietic stem cells (HSC) is unclear. Here, the authors identify a mesenchymal stromal progenitor hierarchy and identify Sca1+ cells as common progenitors for mesenchymal stromal cells in the adult niche that provide a supportive environment for hematopoiesis.

Xingbin Hu
Mayra Garcia
Ching-Cheng Chen
ResearchOpen Access10 Oct 2016
Nature Communications

Volume: 7, P: 1-14
Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia

In chronic myelogenous leukemia, leukemia stem cell function requires a microRNA that is provided by bone marrow endothelial cells.

Bin Zhang
Le Xuan Truong Nguyen
Guido Marcucci
Research05 Mar 2018
Nature Medicine

Volume: 24, P: 450-462
Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy

Yi-Ju Chou
Ching-Cheng Lin
Shu-Ling Fu
ResearchOpen Access21 May 2020
Scientific Reports

Volume: 10, P: 1-15
Mitotic phosphorylation of tumor suppressor DAB2IP maintains spindle assembly checkpoint and chromosomal stability through activating PLK1-Mps1 signal pathway and stabilizing mitotic checkpoint complex

Lan Yu
Yue Lang
Debabrata Saha
ResearchOpen Access13 Nov 2021
Oncogene

Volume: 41, P: 489-501
A feasibility study on non-invasive oxidative metabolism detection and acoustic assessment of human vocal cords by using optical technique

Tzu-Chieh Lin
Jung-Chih Chen
Ching-Cheng Chuang
ResearchOpen Access05 Dec 2017
Scientific Reports

Volume: 7, P: 1-10
Identification of a CD133−CD55− population functions as a fetal common skeletal progenitor

Lihong Weng
Xingbin Hu
Ching-Cheng Chen
ResearchOpen Access08 Dec 2016
Scientific Reports

Volume: 6, P: 1-13

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