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Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

Nasopharyngeal cancer is frequently characterized by Epstein-Barr virus infection. Here, using genomic analyses, the authors find that the tumours harbour mutations in genes involved in the NF-κB signalling pathway or overexpress a viral oncoprotein, latent membrane protein 1.

Yvonne Y Li
Grace T. Y. Chung
Kwok-Wai Lo
ResearchOpen Access18 Jan 2017
Nature Communications

Volume: 8, P: 1-10
Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

The genomic characterisation of nasopharyngeal carcinoma (NPC) remains crucial. Here, the authors perform whole-genome sequencing for 70 NPCs with EBV gene expression, report the somatic alterations and EBV-mediated effects converging on NF-κB activation and immune escape and identify targetable homozygous MTAP deletions.

Jeff P. Bruce
Ka-Fai To
Kwok-Wai Lo
ResearchOpen Access07 Jul 2021
Nature Communications

Volume: 12, P: 1-15
Assessment of programmed cell death ligand-1 expression by 4 diagnostic assays and its clinicopathological correlation in a large cohort of surgical resected non-small cell lung carcinoma

Anthony W. H. Chan
Joanna H. M. Tong
Ka F. To
Research30 Apr 2018
Modern Pathology

Volume: 31, P: 1381-1390
Author Correction: Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Jeff P. Bruce
Ka-Fai To
Kwok-Wai Lo
Amendments and CorrectionsOpen Access27 Jul 2022
Nature Communications

Volume: 13, P: 1
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

The anti-leprosy drug clofazimine inhibits coronavirus replication in several cell models and shows potent antiviral activity against SARS-CoV-2 infection in a hamster model, particularly when used in combination with remdesivir.

Shuofeng Yuan
Xin Yin
Kwok-Yung Yuen
Research16 Mar 2021
Nature

Volume: 593, P: 418-423
Specific targeting of point mutations in EGFR L858R-positive lung cancer by CRISPR/Cas9

Alvin Ho-Kwan Cheung
Chit Chow
Ka-Fai To
Research10 May 2018
Laboratory Investigation

Volume: 98, P: 968-976
A comparability study of immunohistochemical assays for PD-L1 expression in hepatocellular carcinoma

Lei Shi
Shu-Jun Zhang
Anthony Wing-Hung Chan
Research23 Jun 2019
Modern Pathology

Volume: 32, P: 1646-1656

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Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Assessment of programmed cell death ligand-1 expression by 4 diagnostic assays and its clinicopathological correlation in a large cohort of surgical resected non-small cell lung carcinoma

Author Correction: Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

Specific targeting of point mutations in EGFR L858R-positive lung cancer by CRISPR/Cas9

A comparability study of immunohistochemical assays for PD-L1 expression in hepatocellular carcinoma

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Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Assessment of programmed cell death ligand-1 expression by 4 diagnostic assays and its clinicopathological correlation in a large cohort of surgical resected non-small cell lung carcinoma

Author Correction: Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

Specific targeting of point mutations in EGFR L858R-positive lung cancer by CRISPR/Cas9

A comparability study of immunohistochemical assays for PD-L1 expression in hepatocellular carcinoma

Search

Quick links