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Showing 1–2 of 2 results
Advanced filters: Author: Chitrang Trivedi Clear advanced filters

  • The murine G protein-coupled receptor 83 (Gpr83) is expressed widely in the brain, but its physiological role is largely unknown. Here Müller et al.show that Gpr83 regulates systemic energy metabolism in part by modulating ghrelin signalling in the arcuate nucleus of the hypothalamus.

    • Timo D. Müller
    • Anne Müller
    • Matthias H. Tschöp
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-8

  • Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDAC5 regulates leptin sensitivity by deacetylating STAT3.

    • Dhiraj G. Kabra
    • Katrin Pfuhlmann
    • Paul T. Pfluger
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12