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Showing 1–3 of 3 results
Advanced filters: Author: Chongzhi Bai Clear advanced filters

  • YAP is a key oncogenic driver that has long been considered undruggable. Here, the authors present the development of a nanobody-based bioPROTAC that efficiently degrades endogenous YAP, demonstrating potent anticancer activity and providing a promising therapeutic strategy for YAP-dependent tumors.

    • Runhua Zhou
    • Huifang Wang
    • Yi-Lei Li
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • The SARS-CoV-2 spike (S) protein mediates viral entry by binding of its receptor-binding domain (RBD) to the human angiotensin-converting enzyme 2 (ACE2) receptor and mutations of the S protein may have a great impact on virus transmissibility. Here, the authors characterize the interactions of six different SARS-CoV-2 RBD variants among them Alpha, Beta and Gamma and present crystal structures of these ACE2-RBD complexes.

    • Pengcheng Han
    • Chao Su
    • Jianxun Qi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • The SARS-CoV-2 Omicron variant spreads rapidly. Here the authors show that Omicron S preferentially adopts the one-RBD-up conformation, which leads to a non-RBM-binding monoclonal antibody escape. Mutagenesis reveals that S371L, S373P and S375F substitutions enhance the conformational stability.

    • Zhennan Zhao
    • Jingya Zhou
    • George F. Gao
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12