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Showing 1–4 of 4 results
Advanced filters: Author: Chris Chun-Yiu Chan Clear advanced filters

  • SARS-CoV-2 variants of concern such as the Omicron variant pose a challenge for vaccination and antibody immunotherapy. Here, Zhou et al. isolate a broadly neutralizing antibody (bNAb), named ZCB11, that protects Golden Syrian hamsters against Omicron. Applying CryoEM the authors show that ZCB11 heavy chain predominantly interacts with RBD in up confirmation, which interferes with ACE2 receptor binding.

    • Biao Zhou
    • Runhong Zhou
    • Zhiwei Chen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • The anti-leprosy drug clofazimine inhibits coronavirus replication in several cell models and shows potent antiviral activity against SARS-CoV-2 infection in a hamster model, particularly when used in combination with remdesivir.

    • Shuofeng Yuan
    • Xin Yin
    • Kwok-Yung Yuen
    Research
    Nature
    Volume: 593, P: 418-423

  • Although extrapulmonary complications of different organ systems are recognized in patients with severe COVID19 effects are less well studied. Here, Qiao et al. characterize the pathogenesis of SARS-CoV-2 on bone metabolism in Syrian hamster and find that bone loss is associated with virus-mediated cytokine dysregulation.

    • Wei Qiao
    • Hui En Lau
    • Kelvin Wai-Kwok Yeung
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16