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Showing 1–3 of 3 results

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Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection

Mitotic catastrophe is a regulated mechanism that responds to aberrant mitoses leading to removal of damaged cells. Here the authors reveal how replication stress induces mitotic death through pathways regulated by WAPL and telomere deprotection.

V. Pragathi Masamsetti
Ronnie Ren Jie Low
Anthony J. Cesare
ResearchOpen Access17 Sept 2019
Nature Communications

Volume: 10, P: 1-15
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

S63845 specifically inhibits MCL1 and induces tumour cell death in vitro and in vivo in diverse cancer-derived cell lines with an acceptable safety margin.

András Kotschy
Zoltán Szlavik
Olivier Geneste
Research19 Oct 2016
Nature

Volume: 538, P: 477-482
Defining the susceptibility of colorectal cancers to BH3-mimetic compounds

Ming-Jie Luo
Michelle Palmieri
Jia-nan Gong
Comments & OpinionOpen Access10 Sept 2020
Cell Death & Disease

Volume: 11, P: 1-4