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Showing 1–4 of 4 results
Advanced filters: Author: Christiaan N Levelt Clear advanced filters

  • The critical period of ocular dominance (OD) plasticity in the visual cortex is initiated by maturation of inhibition. The authors show that thalamic relay neurons in mouse dorsolateral geniculate nucleus also undergo OD plasticity. This process depends on thalamic inhibition and is required for consolidating the OD shift in visual cortex.

    • Jean-Pierre Sommeijer
    • Mehran Ahmadlou
    • Christiaan N. Levelt
    Research
    Nature Neuroscience
    Volume: 20, P: 1715-1721

  • To study long-term changes in neuronal circuits at single-cell resolution, a Troponin C–based Ca2+ indicator protein has been reengineered to increase the signal strength. This allows repeated measurements, over days and weeks, of orientation selective neurons in mouse visual cortex. Hasan et al., also in this issue, describe the use of a similar sensor for recording neuronal activity in vivo.

    • Marco Mank
    • Alexandre Ferrão Santos
    • Oliver Griesbeck
    Research
    Nature Methods
    Volume: 5, P: 805-811

  • In addition to the neurotropic role of brain-derived neurotrophic factor (BNDF) in cortical circuit plasticity, there is a good positive correlation between the cortical expression level of BDNF and developmental changes in visual acuity. Here, the authors find that directly impairing BDNF signaling using transgenic methods causes visual impairment by affecting the systems level control on contrast gain.

    • J Alexander Heimel
    • M Hadi Saiepour
    • Christiaan N Levelt
    Research
    Nature Neuroscience
    Volume: 13, P: 642-648