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Showing 1–11 of 11 results
Advanced filters: Author: Christian D. Kelstrup Clear advanced filters

  • Ruth Loos and colleagues report a meta-analysis of genome-wide association studies in 181,171 individuals identifying 14 new loci associated with heart rate and test these for association with cardiac conduction, rhythm disorders and cardiovascular disease. Their experimental studies in Drosophila melanogaster and zebrafish models provide support for a role for 20 candidate genes at 11 of these loci in regulation of heart rate.

    • Marcel den Hoed
    • Mark Eijgelsheim
    • Ruth J F Loos
    Research
    Nature Genetics
    Volume: 45, P: 621-631

  • Neuropeptide research is challenged by technical difficulties in identifying new bioactive peptides. Here the authors present an analytical pipeline for large-scale peptidomics applied to the rat hypothalamus, identifying thousands of endogenous neuropeptides and their post-translational modifications.

    • Anna Secher
    • Christian D. Kelstrup
    • Jesper V. Olsen
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Christina Warinner and colleagues report a high-resolution characterization of the oral microbiome isolated from the dental tissues of adult skeletons dating to 1100 CE and showing evidence of periodontal disease. They show the long-term carriage of a diverse range of opportunistic pathogens in the oral cavity and reconstruct the genome of the periodontal pathogen Tannerella forsythia.

    • Christina Warinner
    • João F Matias Rodrigues
    • Enrico Cappellini
    Research
    Nature Genetics
    Volume: 46, P: 336-344

  • Bioactive peptides regulate many physiological functions but progress in discovering them has been slow. Here, the authors use a machine learning framework to predict mammalian peptide candidates from the global and local structure of large-scale tissue-specific mass spectrometry data.

    • Christian T. Madsen
    • Jan C. Refsgaard
    • Ulrik de Lichtenberg
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Localizing phosphorylation sites by data-independent acquisition (DIA)-based proteomics is still challenging. Here, the authors develop algorithms for phosphosite localization and stoichiometry determination, and incorporate them into single-shot DIA-phosphoproteomics workflows.

    • Dorte B. Bekker-Jensen
    • Oliver M. Bernhardt
    • Jesper V. Olsen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Mineralized plaque, or dental calculus, is a valuable reservoir of the ancient oral microbiome. Here, the authors use quantitative metaproteomics to analyze the dental calculus of 21 individuals from a medieval cemetery, identifying human and microbial proteins that shed light on their oral health status.

    • Rosa R. Jersie-Christensen
    • Liam T. Lanigan
    • Jesper V. Olsen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Quantitative phosphoproteomics has become a standard method in molecular and cell biology. Here, the authors compare performance and parameters of phosphoproteome quantification by LFQ, SILAC, and MS2-/MS3-based TMT and introduce a TMT-adapted algorithm for calculating phosphorylation site stoichiometry.

    • Alexander Hogrebe
    • Louise von Stechow
    • Jesper V. Olsen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Palaeoproteomic analysis of dental enamel from an Early Pleistocene Stephanorhinus resolves the phylogeny of Eurasian Rhinocerotidae, by enabling the reconstruction of molecular evolution beyond the limits of ancient DNA preservation.

    • Enrico Cappellini
    • Frido Welker
    • Eske Willerslev
    Research
    Nature
    Volume: 574, P: 103-107

  • Using UbiSite, an antibody-based approach that specifically detects protein lysine and N-terminal ubiquitination, Blagoev and colleagues uncover lack of correlation between changes in protein ubiquitination and abundance upon proteasome inhibition.

    • Vyacheslav Akimov
    • Inigo Barrio-Hernandez
    • Blagoy Blagoev
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 631-640