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Showing 1–9 of 9 results
Advanced filters: Author: Christian Goosmann Clear advanced filters

  • Type three secretion systems consist of a multisubunit protein complex that crosses the bacterial membranes and an extracellular needle-shaped structure. New data show that the needle protomer partially refolds from alpha-helix into beta-strand conformation to extend the needle from the distal end. The closely related flagellar system also grows at the tip, but it is not known whether protomer refolding is required for its assembly.

    • Ömer Poyraz
    • Holger Schmidt
    • Michael Kolbe
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 788-792

  • Here, Koster et al., model human papillomavirus and Chlamydia coinfection dynamics in patient-derived ectocervical organoids, and characterize the effects of multiple infections in the cellular microenvironment, potentially contributing to neoplasia.

    • Stefanie Koster
    • Rajendra Kumar Gurumurthy
    • Cindrilla Chumduri
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • The structure of the needle of the type III secretion system of Salmonella typhimurium, used to inject virulence proteins into host cells during infection, has been resolved by a combination of in vitro needle production, solid-state nuclear magnetic resonance, electron microscopy and Rosetta modelling at atomic resolution.

    • Antoine Loquet
    • Nikolaos G. Sgourakis
    • Adam Lange
    Research
    Nature
    Volume: 486, P: 276-279

  • The pathogen Staphylococcus aureus releases several pore-forming toxins, termed leukocidins, that kill immune cells. Here, Zheng et al. show that the retention of a leukocidin on bacterial cells and its release are modulated by lipoteichoic acid and a membrane lipid, which also control the sorting of other surface-associated proteins.

    • Xuhui Zheng
    • Gerben Marsman
    • Victor J. Torres
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • The mammalian aryl hydrocarbon receptor (known to sense environmental pollutants) is shown to also have a role as a pattern recognition receptor in sensing bacterial virulence factors, resulting in an antibacterial response and activation of innate and natural defences.

    • Pedro Moura-Alves
    • Kellen Faé
    • Stefan H. E. Kaufmann
    Research
    Nature
    Volume: 512, P: 387-392

  • Neutrophils release the serine proteases neutrophil elastase and cathepsin G, which have microbicidal activity and thereby contribute to the innate immune response. Steffen Massberg et al. now show that these neutrophil serine proteases, in association with extracellular nucleosomes, can also promote coagulation and thrombosis within large blood vessels. In a mouse model of systemic bacterial infection, these proteases spurred intravascular coagulation in the microcirculation of the liver, limiting bacterial tissue invasion. These findings point to a role for thrombosis in antimicrobial defense.

    • Steffen Massberg
    • Lenka Grahl
    • Bernd Engelmann
    Research
    Nature Medicine
    Volume: 16, P: 887-896