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Showing 1–5 of 5 results
Advanced filters: Author: Christian Grütter Clear advanced filters

  • Natural products populate areas of chemical space not occupied by average synthetic molecules. Here, an analysis of more than 180,000 natural product structures results in a library of 2,000 natural-product-derived fragments, which resemble the properties of the natural products themselves and give access to novel inhibitor chemotypes.

    • Björn Over
    • Stefan Wetzel
    • Herbert Waldmann
    Research
    Nature Chemistry
    Volume: 5, P: 21-28

  • Studies elucidating the role of p38α MAPK in diverse biological processes are limited by the lack of a specific inhibitor. Skepinone-L is a highly selective ATP-competitive inhibitor of p38 with excellent potency in vivo.

    • Solveigh C Koeberle
    • Johannes Romir
    • Stefan A Laufer
    Research
    Nature Chemical Biology
    Volume: 8, P: 141-143

  • Roman Thomas and colleagues report exome sequencing of 29 small-cell lung cancers (SCLCs), 2 SCLC genomes and transcriptomes of 15 SCLCs. They identify recurrent mutations in the CREBBP, EP300 and MLL genes encoding histone modifiers. They identify mutations in SLIT2 and EPHA7, which have a role in axon guidance and cell migration, and focal amplifications of FGFR1.

    • Martin Peifer
    • Lynnette Fernández-Cuesta
    • Roman K Thomas
    Research
    Nature Genetics
    Volume: 44, P: 1104-1110