Deficits in developmental synaptic pruning are frequently observed in autism. Here the authors demonstrate molecular pathways shared by pruning and long-term depression (LTD), a synaptic memory mechanism in adult brains that is dysregulated in autism. Thus, autism-related pruning deficits may result from the inability to weaken or disconnect inefficient synapses.
- Claire Piochon
- Masanobu Kano
- Christian Hansel