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Showing 1–4 of 4 results
Advanced filters: Author: Christian Kleimeyer Clear advanced filters

  • Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment.

    • Anne Kathrin Lösslein
    • Florens Lohrmann
    • Philipp Henneke
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-22

  • While previous studies had shown the requirement of TGFβ signalling in microglia gene expression, the specificity of the loss-of-function was unclear. Here, Zöller and colleagues generate microglia specific cKO of TGFβ receptor 2, and show dispensable function of Tgfbr2 in microglial survival and the requirement of Tgfbr2 in morphological and transcriptional homeostasis of adult microglia.

    • Tanja Zöller
    • Artur Schneider
    • Björn Spittau
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13