Nature Search

Proteotoxic stress response drives T cell exhaustion and immune evasion

A proteotoxic stress response specific to exhausted T cells, governed by AKT signaling and accompanied by increased protein translation, represents a mechanistic vulnerability and a new therapeutic target to improve cancer immunotherapies.

Yi Wang
Anjun Ma
Zihai Li
ResearchOpen Access01 Oct 2025
Nature

P: 1-11
System-wide identification and prioritization of enzyme substrates by thermal analysis

The global identification of enzyme substrates is still challenging. Here, the authors develop a method based on proteome-wide thermal shift assays to discover enzyme substrates directly from cell lysates, identifying known and novel oxidoreductase, kinase and poly-(ADP-ribose) polymerase substrates.

Amir Ata Saei
Christian M. Beusch
Roman A. Zubarev
ResearchOpen Access26 Feb 2021
Nature Communications

Volume: 12, P: 1-13
ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery

Anticancer drugs often have widespread effects on the cellular proteome. Here, the authors generate a proteome signature library of drug-treated cancer cell lines and develop a software tool to deconvolute drug targets and gain insights into their mechanisms of action.

Amir Ata Saei
Christian Michel Beusch
Roman A. Zubarev
ResearchOpen Access16 Dec 2019
Nature Communications

Volume: 10, P: 1-13
Distinct SIV-specific CD8⁺ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence

Paiardini and colleagues describe a subset of lymph node HIV- and SIV-specific TOX^hiTCF1⁺CD39⁺CD8⁺ T cells that coexhibit stem- and effector-like phenotypic and transcriptional profiles and associate with reduced viral burden.

Zachary Strongin
Laurence Raymond Marchand
Mirko Paiardini
Research17 Jun 2024
Nature Immunology

Volume: 25, P: 1245-1256
GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics

Agonists of the glucagon-like peptide-1 receptor are used to treat diabetes and obesity. Here, Wright et al. investigate the subcellular location of the receptor’s signaling events and uncover associations between signaling profiles and adverse drug reactions.

Shane C. Wright
Aikaterini Motso
Volker M. Lauschke
ResearchOpen Access09 Oct 2023
Nature Communications

Volume: 14, P: 1-13
Copper(I)-nitrene platform for chemoproteomic profiling of methionine

Methionine plays an essential role in various biological and cell regulatory processes, making its chemoproteomic profiling necessary to understand its function. Here, the authors present Copper(I)-Nitrene Platform (CuNiP) for robust and selective labelling of methionine to generate highly stable sulfonyl sulfimide conjugates under physiological conditions.

Samrat Sahu
Benjamin Emenike
Monika Raj
ResearchOpen Access18 May 2024
Nature Communications

Volume: 15, P: 1-18
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis

Although anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis and generally considered pathogenic, their functional relevance is incompletely understood. In this study, the authors describe an ACPA with a protective effect against antibody-induced arthritis in mice.

Yibo He
Changrong Ge
Rikard Holmdahl
ResearchOpen Access08 Feb 2023
Nature Communications

Volume: 14, P: 1-19
An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation

To characterize molecular changes during cell type transitions, the authors develop a method to simultaneously measure protein expression and thermal stability changes. They apply this approach to study differences between human pluripotent stem cells, their progenies, parental and allogeneic cells.

Pierre Sabatier
Christian M. Beusch
Roman A. Zubarev
ResearchOpen Access12 Nov 2021
Nature Communications

Volume: 12, P: 1-16
A multi-tissue longitudinal proteomics study to evaluate the suitability of post-mortem samples for pathophysiological research

Longitudinal proteomics study identifies variability in proteome alterations in different tissues, reveals distinct consensus semitryptic motives in different organs and provides criteria for designing proteomic studies involving post-mortem samples.

Christian M. Beusch
Ken Braesch-Andersen
Sergey Rodin
ResearchOpen Access17 Jan 2025
Communications Biology

Volume: 8, P: 1-10

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