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Showing 1–9 of 9 results
Advanced filters: Author: Christian Perez-Shibayama Clear advanced filters

  • Perez-Shibayama et al. report that BMP4 signaling is downregulated in autoimmune myocarditis. Restoring BMP4 levels with antibodies that neutralize the BMP inhibitors gremlin-1 and gremlin-2 can ameliorate cardiac inflammation and improve function in mouse models.

    • Christian Perez-Shibayama
    • Cristina Gil-Cruz
    • Burkhard Ludewig
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 3, P: 301-316

  • Fat-associated lymphoid clusters (FALCs) are non-classical secondary lymphoid organs of the body cavities. The formation and maturation of FALCs are driven by tumor-necrosis factor and are further enhanced by invariant natural killer T cells.

    • Christian Perez-Shibayama
    • Burkhard Ludewig
    News & Views
    Nature Immunology
    Volume: 16, P: 796-798

  • Fibroblastic reticular cells influence the function of lymphocytes in secondary lymphoid organs. Ludewig and colleagues demonstrate that they also specifically restrain the activation of group 1 innate lymphoid cells in the presence of microbial stimulation to prevent immunopathology.

    • Cristina Gil-Cruz
    • Christian Perez-Shibayama
    • Burkhard Ludewig
    Research
    Nature Immunology
    Volume: 17, P: 1388-1396

  • Pikor et al. show that a set of conserved, bidirectional cues exchanged between fibroblastic reticular cells and immune cells sustain B cell niches, which control humoral immune responses across mouse and human lymphoid organs.

    • Mechthild Lütge
    • Angelina De Martin
    • Natalia B. Pikor
    ResearchOpen Access
    Nature Immunology
    Volume: 24, P: 1149-1160

  • Fibroblastic reticular cells (FRCs) support localisation of immune cells in secondary lymphoid tissues but less is known about the lamina propria. Here the authors use scRNA-seq and intestinal infection to characterise FRCs in the intestinal lamina propria and show specialised niches that foster innate lymphoid cells during homeostasis and infection.

    • Hung-Wei Cheng
    • Urs Mörbe
    • Burkhard Ludewig
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Lymphocytic choriomeningitis virus (LCMV)-based viral vectors have been shown to induce potent antitumor immune responses. Here the authors show that a LCMV-based vaccine vector remodels the tumor-associated fibroblastic stroma, sustaining CD8+ T cell activation and reducing tumor growth in a preclinical model of melanoma.

    • Sandra S. Ring
    • Jovana Cupovic
    • Lukas Flatz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Kollias and colleagues examine the development of fibroblastic reticular cells (FRCs) during lymphoid organogenesis in gut Peyer’s patches (PPs). They show that PP FRCs develop from two separate mesenchymal cell lineages, which converge and form mosaic microenvironments that support immune cell activation and maintain intestinal homeostasis.

    • Alejandro Prados
    • Lucas Onder
    • George Kollias
    Research
    Nature Immunology
    Volume: 22, P: 510-519

  • The replacement of damaged cardiomyocytes by extracellular matrix-producing fibroblasts underpins adverse remodeling in the failing heart. New research finds that MHC class II-dependent fibroblast–CD4+ T cell interactions in the myocardium lead to fibroblast activation and exacerbate fibrotic remodeling of the myocardium.

    • Christian Perez-Shibayama
    • Cristina Gil-Cruz
    • Burkhard Ludewig
    News & Views
    Nature Cardiovascular Research
    Volume: 1, P: 694-695