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Showing 1–7 of 7 results

Advanced filters: Author: Christian Reepmeyer Clear advanced filters

Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88

Proline-rich antimicrobial peptides (PrAMPs) inhibit bacterial protein biosynthesis. Here, the authors show that the honey-bee derived PrAMPs Api137 and Api88 inhibit bacterial ribosomes through multiple mechanisms, promising for drug development.

Simon M. Lauer
Maren Reepmeyer
Ralf Hoffmann
ResearchOpen Access10 May 2024
Nature Communications

Volume: 15, P: 1-19
The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding

Proline-rich antimicrobial peptides (PrAMPs) are inhibitors of bacterial protein synthesis. Here, the authors demonstrate that the antimicrobial peptide Api137 can disrupt assembly of the ribosomal 50S subunit by inducing misfolding of its components.

Simon Malte Lauer
Jakob Gasse
Ralf Hoffmann
ResearchOpen Access10 Jan 2025
Nature Communications

Volume: 16, P: 1-18
Language continuity despite population replacement in Remote Oceania

Genome-wide data from ancient and modern individuals in Remote Oceania indicate population replacement but language continuity over the past 2,500 years. Papuan migrations led to almost complete genetic replacement of in situ East Asian-derived populations, but not replacement of Austronesian languages.

Cosimo Posth
Kathrin Nägele
Adam Powell
Research27 Feb 2018
Nature Ecology & Evolution

Volume: 2, P: 731-740
Genomic insights into the peopling of the Southwest Pacific

Analysis of ancient DNA from four individuals who lived in Vanuatu and Tonga between 2,300 and 3,100 years ago suggests that the Papuan ancestry seen in present-day occupants of this region was introduced at a later date.

Pontus Skoglund
Cosimo Posth
David Reich
Research03 Oct 2016
Nature

Volume: 538, P: 510-513
Earliest known funerary rites in Wallacea after the last glacial maximum

Stuart Hawkins
Gabriella Ayang Zetika
Sue O’Connor
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-18
Early human settlement of Sahul was not an accident

Michael I. Bird
Scott A. Condie
Corey J. A. Bradshaw
ResearchOpen Access17 Jun 2019
Scientific Reports

Volume: 9, P: 1-10
Pofatu, a curated and open-access database for geochemical sourcing of archaeological materials

Aymeric Hermann
Robert Forkel
Marshall Weisler
ResearchOpen Access11 May 2020
Scientific Data

Volume: 7, P: 1-9