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Showing 1–2 of 2 results
Advanced filters: Author: Christian Tränkle Clear advanced filters

  • Class A seven transmembrane helical receptors harbour vestibules at the entrance to the ligand-binding domain. Here, Bocket al. use probes to monitor the conformation of the M2 muscarinic receptor and show that the vestibule alters the extent of receptor movement.

    • Andreas Bock
    • Nicole Merten
    • Klaus Mohr
    ResearchOpen Access
    Nature Communications
    Volume: 3, P: 1-11

  • Partial agonists are generally thought to promote GPCR conformations that signal suboptimally. Analysis of bifunctional muscarinic M2 receptor ligands now shows that partial agonism can also be predictably defined by a single ligand binding two receptor populations in different orientations.

    • Andreas Bock
    • Brian Chirinda
    • Klaus Mohr
    Research
    Nature Chemical Biology
    Volume: 10, P: 18-20