Response to anti-PD-1 in patients with hepatocellular carcinoma is associated with clonal expansion of intratumoral CXCL13+ CD4+ helper T cells and effector-like CD8+ T cells, and local dendritic cells enriched in expression of maturation and regulatory molecules help facilitate CD8+ T cell differentiation.
- Assaf Magen
- Pauline Hamon
- Miriam Merad