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Showing 1–3 of 3 results
Advanced filters: Author: Christina M. Caragine Clear advanced filters

  • The oncogene MYC plays a key role in cancer initiation and progression. Using thousands of CRISPR perturbations, the authors investigate regulators of MYC in six different cancers. These tumor-specific regulators suggest potential therapeutic targets for this oncogene.

    • Christina M. Caragine
    • Victoria T. Le
    • Neville E. Sanjana
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • The advent of CRISPR technologies has enabled programmable nucleic acid editing in mammalian cells. In this Review, Katti et al. outline the enormous progress that has been made in the application of CRISPR tools to the study of cancer and also describe the potential use of CRISPR systems in clinical cancer management including diagnosis and treatment.

    • Alyna Katti
    • Bianca J. Diaz
    • Lukas E. Dow
    Reviews
    Nature Reviews Cancer
    Volume: 22, P: 259-279

  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Reviews
    Nature
    Volume: 633, P: 47-57