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Advanced filters: Author: Christina M. Lucato Clear advanced filters

  • Cryo-EM, X-ray crystallography and crosslinking mass spectrometry are harnessed to solve the structure of the full-length Rho-GEF P-Rex1, uncovering a two-layered mechanism of autoinhibition released upon Gβγ and PI(3,4,5)P3 binding.

    • Yong-Gang Chang
    • Christopher J. Lupton
    • Andrew M. Ellisdon
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 767-773