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Showing 1–29 of 29 results

Advanced filters: Author: Christine Orengo Clear advanced filters

Assessing functional novelty of PSI structures via structure-function analysis of large and diverse superfamilies

Benoit Dessailly
Oliver Redfern
Christine Orengo
ResearchOpen Access22 Aug 2008
Nature Precedings

P: 1
Protein superfamilles and domain superfolds

Christine A. Orengo
David T. Jones
Janet M. Thornton
Reviews15 Dec 1994
Nature

Volume: 372, P: 631-634
Recurrence of a binding motif?

Mark B. Swindells
Christine A. Orengo
Janet M. Thornton
Research25 Mar 1993
Nature

Volume: 362, P: 299
Shared structural motif in proteins

Mark B. Swindells
Christine A. Orengo
Janet M. Thornton
Research02 Sept 1993
Nature

Volume: 365, P: 21
Predicting protein function from sequence and structure

Given the amino-acid sequence or 3D structure of a protein, how much can we predict about its function using just a desktop computer? The recent explosive growth in the volume of sequence data and advancement in computational methods has put more tools at the biologist's disposal than ever before.

David Lee
Oliver Redfern
Christine Orengo
Reviews01 Dec 2007
Nature Reviews Molecular Cell Biology

Volume: 8, P: 995-1005
Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Shilpa Nadimpalli Kobren
Mikhail A. Moldovan
Shamil R. Sunyaev
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-19
A large-scale evaluation of computational protein function prediction

A report on the results of the first large-scale community-based critical assessment of protein function annotation (CAFA) experiment.

Predrag Radivojac
Wyatt T Clark
Iddo Friedberg
ResearchOpen Access27 Jan 2013
Nature Methods

Volume: 10, P: 221-227
Transmission of SARS-CoV-2 from humans to animals and potential host adaptation

Here, Tan et al. find that the rapid spread of SARS-CoV-2 in mink and deer required minimal adaptation, has only caused moderate changes to the evolutionary trajectory of the virus, and has not led to viral mutations that greatly improve human transmission thus far.

Cedric C. S. Tan
Su Datt Lam
François Balloux
ResearchOpen Access27 May 2022
Nature Communications

Volume: 13, P: 1-13
Co-Expression Network Models Suggest that Stress Increases Tolerance to Mutations

Sonja Lehtinen
Jürg Bähler
Christine Orengo
ResearchOpen Access16 Nov 2015
Scientific Reports

Volume: 5, P: 1-8
From structure to function: Approaches and limitations

Janet M. Thornton
Annabel E. Todd
Christine A. Orengo
Reviews01 Nov 2000
Nature Structural Biology

Volume: 7, P: 991-994
Structural and Functional View of Polypharmacology

Aurelio Moya-García
Tolulope Adeyelu
Juan A. G. Ranea
ResearchOpen Access31 Aug 2017
Scientific Reports

Volume: 7, P: 1-14
Predicting human and viral protein variants affecting COVID-19 susceptibility and repurposing therapeutics

Vaishali P. Waman
Paul Ashford
Christine A. Orengo
ResearchOpen Access20 Jun 2024
Scientific Reports

Volume: 14, P: 1-19
Enhancing missense variant pathogenicity prediction with protein language models using VariPred

Weining Lin
Jude Wells
Andrew C. R. Martin
ResearchOpen Access07 Apr 2024
Scientific Reports

Volume: 14, P: 1-13
AlphaFold2 reveals commonalities and novelties in protein structure space for 21 model organisms

A new protein domain classification protocol incorporating deep learning strategies for detecting sequence and structure similarities between domain is used to systematically study and analyse the predicted AlphaFold2 structural models for proteins of 21 organisms.

Nicola Bordin
Ian Sillitoe
Christine Orengo
ResearchOpen Access08 Feb 2023
Communications Biology

Volume: 6, P: 1-12
Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila

Harry M. Scholes
Adam Cryar
Konstantinos Thalassinos
ResearchOpen Access28 Oct 2020
Scientific Reports

Volume: 10, P: 1-13
A CATH domain functional family based approach to identify putative cancer driver genes and driver mutations

Paul Ashford
Camilla S. M. Pang
Christine A. Orengo
ResearchOpen Access22 Jan 2019
Scientific Reports

Volume: 9, P: 1-15
Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts

A diagnostic tool based on blood RNA-seq is shown to identify causal genes and variants linked to clinical phenotypes in individuals with rare diseases for which whole-exome genetic sequencing was uninformative.

Laure Frésard
Craig Smail
Stephen B. Montgomery
Research03 Jun 2019
Nature Medicine

Volume: 25, P: 911-919
Genome-wide RNA-Sequencing analysis identifies a distinct fibrosis gene signature in the conjunctiva after glaucoma surgery

Cynthia Yu-Wai-Man
Nicholas Owen
Peng T. Khaw
ResearchOpen Access17 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
Bi-allelic ATG4D variants are associated with a neurodevelopmental disorder characterized by speech and motor impairment

Marie Morimoto
Vikas Bhambhani
May Christine V. Malicdan
ResearchOpen Access10 Feb 2023
npj Genomic Medicine

Volume: 8, P: 1-16
Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations

Lance H. Rodan
Rebecca C. Spillmann
Vandana Shashi
Research23 Jun 2021
Genetics in Medicine

Volume: 23, P: 1922-1932
An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

Sacha Ferdinandusse
Kirsty McWalter
Frédéric M. Vaz
ResearchOpen Access26 Nov 2020
Genetics in Medicine

Volume: 23, P: 740-750
Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain

Felix Marbach
Georgi Stoyanov
Christian P. Schaaf
ResearchOpen Access08 Apr 2021
Genetics in Medicine

Volume: 23, P: 1465-1473
Heterozygous loss-of-function variants significantly expand the phenotypes associated with loss of GDF11

Thomas A. Ravenscroft
Jennifer B. Phillips
Hugo J. Bellen
Research10 Jun 2021
Genetics in Medicine

Volume: 23, P: 1889-1900
Clinical sites of the Undiagnosed Diseases Network: unique contributions to genomic medicine and science

Kelly Schoch
Cecilia Esteves
Vandana Shashi
Research23 Oct 2020
Genetics in Medicine

Volume: 23, P: 259-271
Commonalities across computational workflows for uncovering explanatory variants in undiagnosed cases

Shilpa Nadimpalli Kobren
Dustin Baldridge
Isaac S. Kohane
ResearchOpen Access12 Feb 2021
Genetics in Medicine

Volume: 23, P: 1075-1085
A resource of lipidomics and metabolomics data from individuals with undiagnosed diseases

Jennifer E. Kyle
Kelly G. Stratton
Thomas O. Metz
ResearchOpen Access21 Apr 2021
Scientific Data

Volume: 8, P: 1-12
One is the loneliest number: genotypic matchmaking using the electronic health record

Elly Brokamp
Mary E. Koziura
Jimann Shin
Comments & Opinion06 Jul 2021
Genetics in Medicine

Volume: 23, P: 1830-1832
Correction: Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations

Lance H. Rodan
Rebecca C. Spillmann
Vandana Shashi
Amendments and Corrections14 Sept 2021
Genetics in Medicine

Volume: 23, P: 2016
Correction to: An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

Sacha Ferdinandusse
Kirsty McWalter
Frédéric M. Vaz
Amendments and CorrectionsOpen Access19 Oct 2021
Genetics in Medicine

Volume: 23, P: 2467

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Assessing functional novelty of PSI structures via structure-function analysis of large and diverse superfamilies

Protein superfamilles and domain superfolds

Recurrence of a binding motif?

Shared structural motif in proteins

Predicting protein function from sequence and structure

Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations

A large-scale evaluation of computational protein function prediction

Transmission of SARS-CoV-2 from humans to animals and potential host adaptation

Co-Expression Network Models Suggest that Stress Increases Tolerance to Mutations

From structure to function: Approaches and limitations

Structural and Functional View of Polypharmacology

Predicting human and viral protein variants affecting COVID-19 susceptibility and repurposing therapeutics

Enhancing missense variant pathogenicity prediction with protein language models using VariPred

AlphaFold2 reveals commonalities and novelties in protein structure space for 21 model organisms

Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila

A CATH domain functional family based approach to identify putative cancer driver genes and driver mutations

Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts

Genome-wide RNA-Sequencing analysis identifies a distinct fibrosis gene signature in the conjunctiva after glaucoma surgery

Bi-allelic ATG4D variants are associated with a neurodevelopmental disorder characterized by speech and motor impairment

Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations

An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain

Heterozygous loss-of-function variants significantly expand the phenotypes associated with loss of GDF11

Clinical sites of the Undiagnosed Diseases Network: unique contributions to genomic medicine and science

Commonalities across computational workflows for uncovering explanatory variants in undiagnosed cases

A resource of lipidomics and metabolomics data from individuals with undiagnosed diseases

One is the loneliest number: genotypic matchmaking using the electronic health record

Correction: Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations

Correction to: An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

Search

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