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Showing 1–2 of 2 results
Advanced filters: Author: Christoph Grondal Clear advanced filters
  • Development of an asymmetric organocatalytic triple cascade able to synthesize tetra-substituted cyclohexene carbaldehydes proceeds through a Michael/Michael/aldol condensation sequence, generating four stereogenic centres with high diastereo- and complete enantiocontrol in good to moderate yields.

    • Dieter Enders
    • Matthias R. M. Hüttl
    • Gerhard Raabe
    Research
    Nature
    Volume: 441, P: 861-863
  • The field of organocatalysis has grown rapidly in the past decade to become, along with metal catalysis and biocatalysis, a third pillar of asymmetric catalysis. Here, progress in the use of organocatalytic cascade reactions for total synthesis is reviewed. The elegance and efficiency of such cascades mean that they have emerged as a powerful tool in synthetic organic chemistry.

    • Christoph Grondal
    • Matthieu Jeanty
    • Dieter Enders
    Reviews
    Nature Chemistry
    Volume: 2, P: 167-178