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Showing 1–3 of 3 results
Advanced filters: Author: Christophe Chardot Clear advanced filters

  • Paediatric liver cancer is rare, and often associated with a predisposition syndrome. Here, the authors show that 11p15.5 mosaic alteration in the liver is a pre-neoplastic lesion associated with hepatoblastoma, and spatial transcriptomics together with single-nucleus RNAseq identify a an altered zonation in the liver of these patients.

    • Jill Pilet
    • Theo Z. Hirsch
    • Jessica Zucman-Rossi
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Hepatoblastoma (HB) is the most frequent paediatric liver tumour with heterogeneous cellular phenotypes that influence clinical outcomes. Here, the authors integrate bulk, single-cell, and spatial multi-omics to characterise HB cells, and find that clonal evolution and epigenetic plasticity shape response to therapy.

    • Amélie Roehrig
    • Theo Z. Hirsch
    • Eric Letouzé
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • de Senneville et al. demonstrate an integrated workflow combining 3D imaging, manual and machine learning-based semi-automatic segmentation, mathematics and infographics to study the spatial organization of patient-derived hepatoblastoma xenograft tissues. Their approach potentially assists investigations of this childhood liver tumour and other types of tumour tissues.

    • Baudouin Denis de Senneville
    • Fatma Zohra Khoubai
    • Christophe F. Grosset
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-10