Nature Search

Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases

Sang-Min Jang
Christophe E. Redon
Mirit I. Aladjem
ReviewsOpen Access02 Oct 2020
Experimental & Molecular Medicine

Volume: 52, P: 1637-1651
The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin

RepID has previously been shown to promote origin firing. Here the authors reveal that RepID regulates replication origins via the recruitment of the CRL4 complex, and prevents re-initiation and unscheduled DNA replication.

Sang-Min Jang
Ya Zhang
Mirit I. Aladjem
ResearchOpen Access17 Jul 2018
Nature Communications

Volume: 9, P: 1-13
The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation

The spindle assembly checkpoint (SAC) safeguards chromosome segregation by regulating the anaphase promoting complex/cyclosome (APC/C), allowing chromosomes to correctly attach to mitotic spindles. Here the authors reveal a role for Cullin–RING ubiquitin ligase complex 4 (CRL4) in regulating metaphase to anaphase transition via BUB3 degradation.

Sang-Min Jang
Jenny F. Nathans
Mirit I. Aladjem
ResearchOpen Access07 Jan 2020
Nature Communications

Volume: 11, P: 1-12
Spotlight on the role of COP1 in tumorigenesis

This Review discusses the links between the E3 ubiquitin ligase COP1 and cancer, as shown by mouse models and human tumour data. It describes the evidence for COP1 targeting both oncoproteins and tumour suppressor proteins for degradation, how these apparently contradictory data might be rectified and the therapeutic implications.

Jean-Christophe Marine
Reviews07 Jun 2012
Nature Reviews Cancer

Volume: 12, P: 455-464
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.

David E. Gordon
Gwendolyn M. Jang
Nevan J. Krogan
Research30 Apr 2020
Nature

Volume: 583, P: 459-468
A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells

Origins of mammalian DNA replication are poorly characterised because they lack an Identifiable consensus sequence. Here the authors identify RepID, a protein that binds to a subset of G-rich replication origins and facilitates initiation from those origins.

Ya Zhang
Liang Huang
Mirit I. Aladjem
ResearchOpen Access08 Jun 2016
Nature Communications

Volume: 7, P: 1-14
RepID as a potential biomarker and therapeutic target for lung neuroendocrine tumor

Jong-Uk Park
Jae-Hyun Jo
Sang-Min Jang
ResearchOpen Access11 Nov 2024
Scientific Reports

Volume: 14, P: 1-10
Gastrectomy promoted diabetes remission involves the molecular clock and epigenetic mechanisms in a rat model of lean type 2 diabetes

Aurélie Le Lay
François Brial
Dominique Gauguier
ResearchOpen Access08 Dec 2025
Scientific Reports

Volume: 16, P: 1-17
Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens

Micheline Fromont-Racine
Jean-Christophe Rain
Pierre Legrain
Research01 Jul 1997
Nature Genetics

Volume: 16, P: 277-282
Dynamics of replication origin over-activation

DNA replication processes are often dysregulated in cancer. Here the authors analyse DNA synthesis patterns in cancer cells undergoing partial genome re-replication to reveal that re-replication exhibits aberrant replication fork dynamics and a skewed distribution of replication initiation that over-duplicates early-replicating genomic regions.

Haiqing Fu
Christophe E. Redon
Mirit I. Aladjem
ResearchOpen Access08 Jun 2021
Nature Communications

Volume: 12, P: 1-15
Common variants at 12q14 and 12q24 are associated with hippocampal volume

Sudha Seshadri and colleagues report a genome-wide association study for hippocampal volume. The authors identify loci at 12q14 and 12q24 associated with this phenotype.

Joshua C Bis
Charles DeCarli
Sudha Seshadri
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 545-551
Isolation of drugs active against mammalian prions using a yeast-based screening assay

Stéphane Bach
Nicolas Talarek
Marc Blondel
Research10 Aug 2003
Nature Biotechnology

Volume: 21, P: 1075-1081
Comprehensive fine mapping of chr12q12-14 and follow-up replication identify activin receptor 1B (ACVR1B) as a muscle strength gene

An Windelinckx
Gunther De Mars
Martine A Thomis
Research10 Nov 2010
European Journal of Human Genetics

Volume: 19, P: 208-215

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Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases

The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin

The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation

Spotlight on the role of COP1 in tumorigenesis

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells

RepID as a potential biomarker and therapeutic target for lung neuroendocrine tumor

Gastrectomy promoted diabetes remission involves the molecular clock and epigenetic mechanisms in a rat model of lean type 2 diabetes

Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens

Dynamics of replication origin over-activation

Common variants at 12q14 and 12q24 are associated with hippocampal volume

Isolation of drugs active against mammalian prions using a yeast-based screening assay

Comprehensive fine mapping of chr12q12-14 and follow-up replication identify activin receptor 1B (ACVR1B) as a muscle strength gene

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