There are two theories of how haematopoeitic cells arise during embryonic development. One is that haematopoietic cells arise from a mesodermal progenitor with both endothelial and haematopoietic potential called the haemangioblast. Another associates the first haematopoietic cells to an endothelial cell with haematopoietic potential, the haemogenic endothelium. This paper shows that both theories are correct. The haemangioblast generates haematopoietic cells through the formation of a haemogenic endothelium intermediate.
- Christophe Lancrin
- Patrycja Sroczynska
- Georges Lacaud
